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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, Gupta VA, Chandrakasan S, Zoine JT, Fedanov A, Raikar SS, Koff JL, Flowers CR, Coma S, Pachter JA, Ravindranathan S, Spencer HT, Shanmugam M, Waller EK. Funk CR, et al. Among authors: chen kz. Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597. Blood. 2022. PMID: 35084470 Free PMC article.
Germline mutations: many roles in leukemogenesis.
Chen KZ, Kazi R, Porter CC, Qu CK. Chen KZ, et al. Curr Opin Hematol. 2020 Jul;27(4):288-293. doi: 10.1097/MOH.0000000000000596. Curr Opin Hematol. 2020. PMID: 32487806 Free PMC article. Review.
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