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mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: chen j. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: chen j. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.
HSPB7 is indispensable for heart development by modulating actin filament assembly.
Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J. Wu T, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961. doi: 10.1073/pnas.1713763114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078393 Free PMC article.
Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages.
Moore-Morris T, Cattaneo P, Guimarães-Camboa N, Bogomolovas J, Cedenilla M, Banerjee I, Ricote M, Kisseleva T, Zhang L, Gu Y, Dalton ND, Peterson KL, Chen J, Pucéat M, Evans SM. Moore-Morris T, et al. Among authors: chen j. Circ Res. 2018 Feb 16;122(4):583-590. doi: 10.1161/CIRCRESAHA.117.311490. Epub 2017 Dec 21. Circ Res. 2018. PMID: 29269349 Free PMC article.
P209L mutation in Bag3 does not cause cardiomyopathy in mice.
Fang X, Bogomolovas J, Zhou PS, Mu Y, Ma X, Chen Z, Zhang L, Zhu M, Veevers J, Ouyang K, Chen J. Fang X, et al. Among authors: chen z, chen j. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H392-H399. doi: 10.1152/ajpheart.00714.2018. Epub 2018 Nov 30. Am J Physiol Heart Circ Physiol. 2019. PMID: 30499714 Free PMC article.
Atypical ALPK2 kinase is not essential for cardiac development and function.
Bogomolovas J, Feng W, Yu MD, Huang S, Zhang L, Trexler C, Gu Y, Spinozzi S, Chen J. Bogomolovas J, et al. Among authors: chen j. Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1509-H1515. doi: 10.1152/ajpheart.00249.2020. Epub 2020 May 8. Am J Physiol Heart Circ Physiol. 2020. PMID: 32383995 Free PMC article.
Understanding the molecular basis of cardiomyopathy.
Bang ML, Bogomolovas J, Chen J. Bang ML, et al. Among authors: chen j. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H181-H233. doi: 10.1152/ajpheart.00562.2021. Epub 2021 Nov 19. Am J Physiol Heart Circ Physiol. 2022. PMID: 34797172 Free PMC article. Review.
Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct.
Yu Z, Zhang L, Cattaneo P, Guimarães-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM. Yu Z, et al. Among authors: chen j. Circulation. 2023 Jan 10;147(2):183-186. doi: 10.1161/CIRCULATIONAHA.122.061018. Epub 2023 Jan 9. Circulation. 2023. PMID: 36622904 Free PMC article. No abstract available.
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