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Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Liu C, Martins AJ, Lau WW, Rachmaninoff N, Chen J, Imberti L, Mostaghimi D, Fink DL, Burbelo PD, Dobbs K, Delmonte OM, Bansal N, Failla L, Sottini A, Quiros-Roldan E, Han KL, Sellers BA, Cheung F, Sparks R, Chun TW, Moir S, Lionakis MS; NIAID COVID Consortium; COVID Clinicians; Rossi C, Su HC, Kuhns DB, Cohen JI, Notarangelo LD, Tsang JS. Liu C, et al. Among authors: chen j. Cell. 2021 Apr 1;184(7):1836-1857.e22. doi: 10.1016/j.cell.2021.02.018. Epub 2021 Feb 10. Cell. 2021. PMID: 33713619 Free PMC article.
Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.
Ito S, Bollard CM, Carlsten M, Melenhorst JJ, Biancotto A, Wang E, Chen J, Kotliarov Y, Cheung F, Xie Z, Marincola F, Tanimoto K, Battiwalla M, Olnes MJ, Perl S, Schum P, Hughes TE, Keyvanfar K, Hensel N, Muranski P, Young NS, Barrett AJ. Ito S, et al. Among authors: chen j. Mol Ther. 2014 Jul;22(7):1388-1395. doi: 10.1038/mt.2014.50. Epub 2014 Apr 1. Mol Ther. 2014. PMID: 24686272 Free PMC article.
Effects of Systemically Administered Hydrocortisone on the Human Immunome.
Olnes MJ, Kotliarov Y, Biancotto A, Cheung F, Chen J, Shi R, Zhou H, Wang E, Tsang JS, Nussenblatt R; CHI Consortium. Olnes MJ, et al. Among authors: chen j. Sci Rep. 2016 Mar 14;6:23002. doi: 10.1038/srep23002. Sci Rep. 2016. PMID: 26972611 Free PMC article. Clinical Trial.
Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy.
Goswami M, Prince G, Biancotto A, Moir S, Kardava L, Santich BH, Cheung F, Kotliarov Y, Chen J, Shi R, Zhou H, Golding H, Manischewitz J, King L, Kunz LM, Noonan K, Borrello IM, Smith BD, Hourigan CS. Goswami M, et al. Among authors: chen j. J Transl Med. 2017 Jul 10;15(1):155. doi: 10.1186/s12967-017-1252-2. J Transl Med. 2017. PMID: 28693586 Free PMC article.
The Immunome in Two Inherited Forms of Pulmonary Fibrosis.
El-Chemaly S, Cheung F, Kotliarov Y, O'Brien KJ, Gahl WA, Chen J, Perl SY, Biancotto A, Gochuico BR. El-Chemaly S, et al. Among authors: chen j. Front Immunol. 2018 Jan 31;9:76. doi: 10.3389/fimmu.2018.00076. eCollection 2018. Front Immunol. 2018. PMID: 29445374 Free PMC article.
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.
Kotliarov Y, Sparks R, Martins AJ, Mulè MP, Lu Y, Goswami M, Kardava L, Banchereau R, Pascual V, Biancotto A, Chen J, Schwartzberg PL, Bansal N, Liu CC, Cheung F, Moir S, Tsang JS. Kotliarov Y, et al. Among authors: chen j. Nat Med. 2020 Apr;26(4):618-629. doi: 10.1038/s41591-020-0769-8. Epub 2020 Feb 24. Nat Med. 2020. PMID: 32094927 Free PMC article.
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy.
Apps R, Kotliarov Y, Cheung F, Han KL, Chen J, Biancotto A, Babyak A, Zhou H, Shi R, Barnhart L, Osgood SM, Belkaid Y, Holland SM, Tsang JS, Zerbe CS. Apps R, et al. Among authors: chen j. JCI Insight. 2020 Apr 9;5(7):e134838. doi: 10.1172/jci.insight.134838. JCI Insight. 2020. PMID: 32163376 Free PMC article. Clinical Trial.
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