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The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. Carmona-Gutierrez D, et al. Among authors: chen g. Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w. Nat Commun. 2019. PMID: 30783116 Free PMC article.
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy.
Yang H, Ma Y, Chen G, Zhou H, Yamazaki T, Klein C, Pietrocola F, Vacchelli E, Souquere S, Sauvat A, Zitvogel L, Kepp O, Kroemer G. Yang H, et al. Among authors: chen g. Oncoimmunology. 2016 Mar 10;5(6):e1149673. doi: 10.1080/2162402X.2016.1149673. eCollection 2016 Jun. Oncoimmunology. 2016. PMID: 27471616 Free PMC article.
Identification of pharmacological agents that induce HMGB1 release.
Liu P, Zhao L, Loos F, Iribarren K, Lachkar S, Zhou H, Gomes-da-Silva LC, Chen G, Bezu L, Boncompain G, Perez F, Zitvogel L, Kepp O, Kroemer G. Liu P, et al. Among authors: chen g. Sci Rep. 2017 Nov 2;7(1):14915. doi: 10.1038/s41598-017-14848-1. Sci Rep. 2017. PMID: 29097772 Free PMC article.
Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy.
Sica V, Bravo-San Pedro JM, Chen G, Mariño G, Lachkar S, Izzo V, Maiuri MC, Niso-Santano M, Kroemer G. Sica V, et al. Among authors: chen g. Oncotarget. 2017 Jul 6;8(52):89527-89538. doi: 10.18632/oncotarget.19033. eCollection 2017 Oct 27. Oncotarget. 2017. PMID: 29163768 Free PMC article.
Aspirin Recapitulates Features of Caloric Restriction.
Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G. Pietrocola F, et al. Among authors: chen g. Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024. Cell Rep. 2018. PMID: 29490275 Free PMC article.
Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids.
Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G. Sauvat A, et al. Among authors: chen g. EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27. EBioMedicine. 2018. PMID: 29606629 Free PMC article.
Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux.
Zhang S, Wang Y, Xie W, Howe ENW, Busschaert N, Sauvat A, Leduc M, Gomes-da-Silva LC, Chen G, Martins I, Deng X, Maiuri L, Kepp O, Soussi T, Gale PA, Zamzami N, Kroemer G. Zhang S, et al. Among authors: chen g. Cell Death Dis. 2019 Mar 11;10(3):242. doi: 10.1038/s41419-019-1474-8. Cell Death Dis. 2019. PMID: 30858361 Free PMC article.
3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB.
Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G. Chen G, et al. EMBO Mol Med. 2019 Nov 7;11(11):e10469. doi: 10.15252/emmm.201910469. Epub 2019 Oct 14. EMBO Mol Med. 2019. PMID: 31609086 Free PMC article.
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