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Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus.
Negatu DA, Beuchel A, Madani A, Alvarez N, Chen C, Aragaw WW, Zimmerman MD, Laleu B, Gengenbacher M, Dartois V, Imming P, Dick T. Negatu DA, et al. Among authors: chen c. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0067621. doi: 10.1128/AAC.00676-21. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34001512 Free PMC article.
Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.
Chen C, Gardete S, Jansen RS, Shetty A, Dick T, Rhee KY, Dartois V. Chen C, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02107-17. doi: 10.1128/AAC.02107-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463541 Free PMC article.
Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.
Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB. Williams JT, et al. Among authors: chen c. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00547-19. doi: 10.1128/AAC.00547-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405862 Free PMC article.
Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.
Zimmerman M, Lestner J, Prideaux B, O'Brien P, Dias-Freedman I, Chen C, Dietzold J, Daudelin I, Kaya F, Blanc L, Chen PY, Park S, Salgame P, Sarathy J, Dartois V. Zimmerman M, et al. Among authors: chen c, chen py. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00924-17. doi: 10.1128/AAC.00924-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28696241 Free PMC article.
The association between sterilizing activity and drug distribution into tuberculosis lesions.
Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Among authors: chen c, chen py. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.
Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice.
Irwin SM, Prideaux B, Lyon ER, Zimmerman MD, Brooks EJ, Schrupp CA, Chen C, Reichlen MJ, Asay BC, Voskuil MI, Nuermberger EL, Andries K, Lyons MA, Dartois V, Lenaerts AJ. Irwin SM, et al. Among authors: chen c. ACS Infect Dis. 2016 Apr 8;2(4):251-267. doi: 10.1021/acsinfecdis.5b00127. Epub 2016 Feb 24. ACS Infect Dis. 2016. PMID: 27227164 Free PMC article.
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