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A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.
Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M. Law JL, et al. Among authors: chen c. PLoS One. 2013;8(3):e59776. doi: 10.1371/journal.pone.0059776. Epub 2013 Mar 19. PLoS One. 2013. PMID: 23527266 Free PMC article.
Native Folding of a Recombinant gpE1/gpE2 Heterodimer Vaccine Antigen from a Precursor Protein Fused with Fc IgG.
Logan M, Law J, Wong JAJ, Hockman D, Landi A, Chen C, Crawford K, Kundu J, Baldwin L, Johnson J, Dahiya A, LaChance G, Marcotrigiano J, Law M, Foung S, Tyrrell L, Houghton M. Logan M, et al. Among authors: chen c. J Virol. 2016 Dec 16;91(1):e01552-16. doi: 10.1128/JVI.01552-16. Print 2017 Jan 1. J Virol. 2016. PMID: 27795422 Free PMC article.
A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1.
Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M. Johnson J, et al. Among authors: chen c. J Virol. 2019 Oct 29;93(22):e00810-19. doi: 10.1128/JVI.00810-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462563 Free PMC article.
Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.
Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD, Law LM, Chen C, Addison WR, Nelson R, Houghton M, Lehner R, Kneteman NM. Nourbakhsh M, et al. Among authors: chen c. J Hepatol. 2013 Aug;59(2):336-43. doi: 10.1016/j.jhep.2013.03.022. Epub 2013 Mar 28. J Hepatol. 2013. PMID: 23542347
AI-Generated Clinical Summaries.
Chen C, Thornton JE. Chen C, et al. JAMA. 2024 May 16. doi: 10.1001/jama.2024.7277. Online ahead of print. JAMA. 2024. PMID: 38753346 No abstract available.
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