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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.
Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M. Friedel RH, et al. Among authors: chen b. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. doi: 10.1073/pnas.0505474102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129827 Free PMC article.
TBR1 regulates autism risk genes in the developing neocortex.
Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G. Notwell JH, et al. Among authors: chen b. Genome Res. 2016 Aug;26(8):1013-22. doi: 10.1101/gr.203612.115. Epub 2016 Jun 20. Genome Res. 2016. PMID: 27325115 Free PMC article.
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ. Kim GB, et al. Among authors: chen b. Cell. 2019 Sep 19;179(1):251-267.e24. doi: 10.1016/j.cell.2019.08.013. Cell. 2019. PMID: 31539496 Free PMC article.
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