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Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.
López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E. López-Ureña D, et al. Toxins (Basel). 2019 Jun 17;11(6):348. doi: 10.3390/toxins11060348. Toxins (Basel). 2019. PMID: 31212980 Free PMC article.
Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.
Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T, Freire R, Guzmán-Verri C, del Mar Gamboa-Coronado M, Lawley TD, Moreno E, Mulvey MR, de Castro Brito GA, Rodríguez-Cavallini E, Rodríguez C, Chaves-Olarte E. Quesada-Gómez C, et al. J Clin Microbiol. 2015 Apr;53(4):1216-26. doi: 10.1128/JCM.03058-14. Epub 2015 Feb 4. J Clin Microbiol. 2015. PMID: 25653402 Free PMC article.
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.
Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Quesada-Gómez C, et al. Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15. Infect Immun. 2016. PMID: 26755157 Free PMC article.
A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption.
Costa CL, López-Ureña D, de Oliveira Assis T, Ribeiro RA, Silva RO, Rupnik M, Wilcox MH, de Carvalho AF, do Carmo AO, Dias AA, de Carvalho CB, Chaves-Olarte E, Rodríguez C, Quesada-Gómez C, de Castro Brito GA. Costa CL, et al. Anaerobe. 2016 Aug;40:76-84. doi: 10.1016/j.anaerobe.2016.06.005. Epub 2016 Jun 14. Anaerobe. 2016. PMID: 27311833 Free article.
Clostridium difficile Infection.
Shin JH, Chaves-Olarte E, Warren CA. Shin JH, et al. Microbiol Spectr. 2016 Jun;4(3):10.1128/microbiolspec.EI10-0007-2015. doi: 10.1128/microbiolspec.EI10-0007-2015. Microbiol Spectr. 2016. PMID: 27337475 Free PMC article. Review.
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.
Ramírez-Vargas G, Quesada-Gómez C, Acuña-Amador L, López-Ureña D, Murillo T, Del Mar Gamboa-Coronado M, Chaves-Olarte E, Thomson N, Rodríguez-Cavallini E, Rodríguez C. Ramírez-Vargas G, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02054-16. doi: 10.1128/AAC.02054-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28137804 Free PMC article.
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements.
Ramírez-Vargas G, López-Ureña D, Badilla A, Orozco-Aguilar J, Murillo T, Rojas P, Riedel T, Overmann J, González G, Chaves-Olarte E, Quesada-Gómez C, Rodríguez C. Ramírez-Vargas G, et al. Sci Rep. 2018 Sep 17;8(1):13951. doi: 10.1038/s41598-018-32390-6. Sci Rep. 2018. PMID: 30224751 Free PMC article.
74 results