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Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation.
Souza TML, Pinho VD, Setim CF, Sacramento CQ, Marcon R, Fintelman-Rodrigues N, Chaves OA, Heller M, Temerozo JR, Ferreira AC, Mattos M, Momo PB, Dias SSG, Gesto JSM, Pereira-Dutra F, Viola JPB, Queiroz-Junior CM, Guimarães LC, Chaves IM, Guimarães PPG, Costa VV, Teixeira MM, Bou-Habib DC, Bozza PT, Aguillón AR, Siqueira-Junior J, Macedo-Junior S, Andrade EL, Fadanni GP, Tolouei SEL, Potrich FB, Santos AA, Marques NF, Calixto JB, Rabi JA. Souza TML, et al. Among authors: chaves im, chaves oa. Nat Commun. 2023 Jan 13;14(1):199. doi: 10.1038/s41467-023-35928-z. Nat Commun. 2023. PMID: 36639383 Free PMC article.
Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo.
Chaves OA, Sacramento CQ, Ferreira AC, Mattos M, Fintelman-Rodrigues N, Temerozo JR, Vazquez L, Pinto DP, da Silveira GPE, da Fonseca LB, Pereira HM, Carlos AS, d'Avila JC, Viola JPB, Monteiro RQ, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Pharmaceuticals (Basel). 2021 Dec 24;15(1):21. doi: 10.3390/ph15010021. Pharmaceuticals (Basel). 2021. PMID: 35056078 Free PMC article.
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J. Wang X, et al. Among authors: chaves oa. Commun Biol. 2022 Feb 22;5(1):154. doi: 10.1038/s42003-022-03101-9. Commun Biol. 2022. PMID: 35194144 Free PMC article.
Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.
Sacramento CQ, Fintelman-Rodrigues N, Dias SSG, Temerozo JR, Da Silva APD, da Silva CS, Blanco C, Ferreira AC, Mattos M, Soares VC, Pereira-Dutra F, Miranda MD, Barreto-Vieira DF, da Silva MAN, Santos SS, Torres M, Chaves OA, Rajoli RKR, Paccanaro A, Owen A, Bou-Habib DC, Bozza PT, Souza TML. Sacramento CQ, et al. Among authors: chaves oa. Viruses. 2022 Feb 11;14(2):374. doi: 10.3390/v14020374. Viruses. 2022. PMID: 35215969 Free PMC article.
51 results