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Human Monocytes Engage an Alternative Inflammasome Pathway.
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V. Gaidt MM, et al. Among authors: chauhan d. Immunity. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. Immunity. 2016. PMID: 27037191 Free article.
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. Mankan AK, et al. Among authors: chauhan d. EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. EMBO J. 2014. PMID: 25425575 Free PMC article.
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E. von Gamm M, et al. Among authors: chauhan d. J Exp Med. 2019 Jul 1;216(7):1700-1723. doi: 10.1084/jem.20181762. Epub 2019 May 24. J Exp Med. 2019. PMID: 31126966 Free PMC article.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Roth S, et al. Among authors: chauhan d. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667383 Free article.
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. Schmacke NA, et al. Among authors: chauhan d. Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Immunity. 2022. PMID: 36384135 Free PMC article.
Therapeutic modulation of inflammasome pathways.
Chauhan D, Vande Walle L, Lamkanfi M. Chauhan D, et al. Immunol Rev. 2020 Sep;297(1):123-138. doi: 10.1111/imr.12908. Epub 2020 Aug 7. Immunol Rev. 2020. PMID: 32770571 Free PMC article. Review.
899 results