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Withaferin A Analogs That Target the AAA+ Chaperone p97.
Tao S, Tillotson J, Wijeratne EMK, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, Clair JJ, Gunatilaka AAL, Zhang DD, Chapman E. Tao S, et al. Among authors: chapman e. ACS Chem Biol. 2015 Aug 21;10(8):1916-1924. doi: 10.1021/acschembio.5b00367. Epub 2015 Jun 3. ACS Chem Biol. 2015. PMID: 26006219 Free PMC article.
USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. Villeneuve NF, et al. Among authors: chapman e. Mol Cell. 2013 Jul 11;51(1):68-79. doi: 10.1016/j.molcel.2013.04.022. Epub 2013 May 30. Mol Cell. 2013. PMID: 23727018 Free PMC article.
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis.
Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD. Wu T, et al. Among authors: chapman e. Genes Dev. 2014 Apr 1;28(7):708-22. doi: 10.1101/gad.238246.114. Epub 2014 Mar 17. Genes Dev. 2014. PMID: 24636985 Free PMC article.
Oncogenic KRAS confers chemoresistance by upregulating NRF2.
Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Tao S, et al. Among authors: chapman e. Cancer Res. 2014 Dec 15;74(24):7430-41. doi: 10.1158/0008-5472.CAN-14-1439. Epub 2014 Oct 22. Cancer Res. 2014. PMID: 25339352 Free PMC article.
Functional chromatographic technique for natural product isolation.
Lau EC, Mason DJ, Eichhorst N, Engelder P, Mesa C, Kithsiri Wijeratne EM, Gunaherath GM, Gunatilaka AA, La Clair JJ, Chapman E. Lau EC, et al. Among authors: chapman e. Org Biomol Chem. 2015 Feb 28;13(8):2255-9. doi: 10.1039/c4ob02292k. Org Biomol Chem. 2015. PMID: 25588099 Free PMC article.
Inhibitors of the AAA+ chaperone p97.
Chapman E, Maksim N, de la Cruz F, La Clair JJ. Chapman E, et al. Molecules. 2015 Feb 12;20(2):3027-49. doi: 10.3390/molecules20023027. Molecules. 2015. PMID: 25685910 Free PMC article. Review.
837 results