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Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses.
Jossi SE, Arcuri M, Alshayea A, Persaud RR, Marcial-Juárez E, Palmieri E, Di Benedetto R, Pérez-Toledo M, Pillaye J, Channell WM, Schager AE, Lamerton RE, Cook CN, Goodall M, Haneda T, Bäumler AJ, Jackson-Jones LH, Toellner KM, MacLennan CA, Henderson IR, Micoli F, Cunningham AF. Jossi SE, et al. Among authors: channell wm. Front Immunol. 2023 Mar 23;14:1139329. doi: 10.3389/fimmu.2023.1139329. eCollection 2023. Front Immunol. 2023. PMID: 37033932 Free PMC article.
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.
Domínguez-Medina CC, Pérez-Toledo M, Schager AE, Marshall JL, Cook CN, Bobat S, Hwang H, Chun BJ, Logan E, Bryant JA, Channell WM, Morris FC, Jossi SE, Alshayea A, Rossiter AE, Barrow PA, Horsnell WG, MacLennan CA, Henderson IR, Lakey JH, Gumbart JC, López-Macías C, Bavro VN, Cunningham AF. Domínguez-Medina CC, et al. Among authors: channell wm. Nat Commun. 2020 Feb 12;11(1):851. doi: 10.1038/s41467-020-14655-9. Nat Commun. 2020. PMID: 32051408 Free PMC article.
Mice Deficient in T-bet Form Inducible NO Synthase-Positive Granulomas That Fail to Constrain Salmonella.
Perez-Toledo M, Beristain-Covarrubias N, Channell WM, Hitchcock JR, Cook CN, Coughlan RE, Bobat S, Jones ND, Nakamura K, Ross EA, Rossiter AE, Rooke J, Garcia-Gimenez A, Jossi S, Persaud RR, Marcial-Juarez E, Flores-Langarica A, Henderson IR, Withers DR, Watson SP, Cunningham AF. Perez-Toledo M, et al. Among authors: channell wm. J Immunol. 2020 Aug 1;205(3):708-719. doi: 10.4049/jimmunol.2000089. Epub 2020 Jun 26. J Immunol. 2020. PMID: 32591391 Free PMC article.
Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps.
Beristain-Covarrubias N, Perez-Toledo M, Flores-Langarica A, Zuidscherwoude M, Hitchcock JR, Channell WM, King LDW, Thomas MR, Henderson IR, Rayes J, Watson SP, Cunningham AF. Beristain-Covarrubias N, et al. Among authors: channell wm. Blood. 2019 Feb 7;133(6):600-604. doi: 10.1182/blood-2018-08-867267. Epub 2018 Nov 6. Blood. 2019. PMID: 30401709 Free PMC article.
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.
Wittner J, Schulz SR, Steinmetz TD, Berges J, Hauke M, Channell WM, Cunningham AF, Hauser AE, Hutloff A, Mielenz D, Jäck HM, Schuh W. Wittner J, et al. Among authors: channell wm. Mucosal Immunol. 2022 Apr;15(4):668-682. doi: 10.1038/s41385-022-00503-0. Epub 2022 Mar 28. Mucosal Immunol. 2022. PMID: 35347229 Free PMC article.