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Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.
Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, Kim H, Jammula S, He Y, Lippman SM, Verhaak RGW, Maley CC, Alexandrov LB, Reid BJ, Fitzgerald RC, Paulson TG, Chang HY, Wu S, Bafna V, Mischel PS. Luebeck J, et al. Among authors: chang hy. Nature. 2023 Apr;616(7958):798-805. doi: 10.1038/s41586-023-05937-5. Epub 2023 Apr 12. Nature. 2023. PMID: 37046089 Free PMC article.
ATAC Primer Tool for targeted analysis of accessible chromatin.
Yost KE, Carter AC, Xu J, Litzenburger U, Chang HY. Yost KE, et al. Among authors: chang hy. Nat Methods. 2018 Apr 27;15(5):304-305. doi: 10.1038/nmeth.4663. Nat Methods. 2018. PMID: 29702633 Free PMC article. No abstract available.
Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Wu S, et al. Among authors: chang hy. Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20. Nature. 2019. PMID: 31748743 Free PMC article.
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim H, Nguyen NP, Turner K, Wu S, Gujar AD, Luebeck J, Liu J, Deshpande V, Rajkumar U, Namburi S, Amin SB, Yi E, Menghi F, Schulte JH, Henssen AG, Chang HY, Beck CR, Mischel PS, Bafna V, Verhaak RGW. Kim H, et al. Among authors: chang hy. Nat Genet. 2020 Sep;52(9):891-897. doi: 10.1038/s41588-020-0678-2. Epub 2020 Aug 17. Nat Genet. 2020. PMID: 32807987 Free PMC article.
Extrachromosomal DNA: An Emerging Hallmark in Human Cancer.
Wu S, Bafna V, Chang HY, Mischel PS. Wu S, et al. Among authors: chang hy. Annu Rev Pathol. 2022 Jan 24;17:367-386. doi: 10.1146/annurev-pathmechdis-051821-114223. Epub 2021 Nov 9. Annu Rev Pathol. 2022. PMID: 34752712 Free PMC article. Review.
ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY. Hung KL, et al. Among authors: chang hy. Nature. 2021 Dec;600(7890):731-736. doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819668 Free PMC article.
Oncogene Convergence in Extrachromosomal DNA Hubs.
Weiser NE, Hung KL, Chang HY. Weiser NE, et al. Among authors: chang hy. Cancer Discov. 2022 May 2;12(5):1195-1198. doi: 10.1158/2159-8290.CD-22-0076. Cancer Discov. 2022. PMID: 35398879 Free PMC article.
Gene regulation on extrachromosomal DNA.
Hung KL, Mischel PS, Chang HY. Hung KL, et al. Among authors: chang hy. Nat Struct Mol Biol. 2022 Aug;29(8):736-744. doi: 10.1038/s41594-022-00806-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948767 Free PMC article. Review.
The evolutionary dynamics of extrachromosomal DNA in human cancers.
Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE, Shi Q, Erb ML, Rajkumar U, Wu S, Taschner-Mandl S, Bernkopf M, Swanton C, Liu Z, Huang W, Chang HY, Bafna V, Henssen AG, Werner B, Mischel PS. Lange JT, et al. Among authors: chang hy. Nat Genet. 2022 Oct;54(10):1527-1533. doi: 10.1038/s41588-022-01177-x. Epub 2022 Sep 19. Nat Genet. 2022. PMID: 36123406 Free PMC article.
2,106 results