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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ. Burgos-Barragan G, et al. Among authors: chang cj. Nature. 2017 Aug 31;548(7669):549-554. doi: 10.1038/nature23481. Epub 2017 Aug 16. Nature. 2017. PMID: 28813411 Free PMC article.
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Tomalin LE, et al. Among authors: chang cj. Free Radic Biol Med. 2016 Jun;95:333-48. doi: 10.1016/j.freeradbiomed.2016.02.035. Epub 2016 Mar 2. Free Radic Biol Med. 2016. PMID: 26944189 Free PMC article.
Fluorescent probes for imaging formaldehyde in biological systems.
Bruemmer KJ, Brewer TF, Chang CJ. Bruemmer KJ, et al. Among authors: chang cj. Curr Opin Chem Biol. 2017 Aug;39:17-23. doi: 10.1016/j.cbpa.2017.04.010. Epub 2017 May 18. Curr Opin Chem Biol. 2017. PMID: 28527906 Free PMC article. Review.
1,908 results