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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Weisser NE, Sanches M, Escobar-Cabrera E, O'Toole J, Whalen E, Chan PWY, Wickman G, Abraham L, Choi K, Harbourne B, Samiotakis A, Rojas AH, Volkers G, Wong J, Atkinson CE, Baardsnes J, Worrall LJ, Browman D, Smith EE, Baichoo P, Cheng CW, Guedia J, Kang S, Mukhopadhyay A, Newhook L, Ohrn A, Raghunatha P, Zago-Schmitt M, Schrag JD, Smith J, Zwierzchowski P, Scurll JM, Fung V, Black S, Strynadka NCJ, Gold MR, Presta LG, Ng G, Dixit S. Weisser NE, et al. Among authors: chan pwy. Nat Commun. 2023 Mar 13;14(1):1394. doi: 10.1038/s41467-023-37029-3. Nat Commun. 2023. PMID: 36914633 Free PMC article.
Resolution of structural heterogeneity in dynamic crystallography.
Ren Z, Chan PW, Moffat K, Pai EF, Royer WE Jr, Šrajer V, Yang X. Ren Z, et al. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):946-59. doi: 10.1107/S0907444913003454. Epub 2013 May 2. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23695239 Free PMC article.