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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: chan kc. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.
Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma.
Fitzsimmons CM, Mandler MD, Lunger JC, Chan D, Maligireddy SS, Schmiechen AC, Gamage ST, Link C, Jenkins LM, Chan K, Andresson T, Crooks DR, Meier JL, Linehan WM, Batista PJ. Fitzsimmons CM, et al. NAR Cancer. 2024 Feb 7;6(1):zcae004. doi: 10.1093/narcan/zcae004. eCollection 2024 Mar. NAR Cancer. 2024. PMID: 38328795 Free PMC article.
A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.
Ligon JA, Sundby RT, Wedekind MF, Arnaldez FI, Del Rivero J, Wiener L, Srinivasan R, Spencer M, Carbonell A, Lei H, Shern J, Steinberg SM, Figg WD, Peer CJ, Zimmerman S, Moraly J, Xu X, Fox S, Chan K, Barbato MI, Andresson T, Taylor N, Pacak K, Killian JK, Dombi E, Linehan WM, Miettinen M, Piekarz R, Helman LJ, Meltzer P, Widemann B, Glod J. Ligon JA, et al. Clin Cancer Res. 2023 Jan 17;29(2):341-348. doi: 10.1158/1078-0432.CCR-22-2168. Clin Cancer Res. 2023. PMID: 36302175 Free PMC article. Clinical Trial.
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment.
Wei CH, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, Kawakami M, Chen Z, Shi M, Kozlov S, Chan KC, Andresson T, Carrington M, Vuligonda V, Sanders ME, Horowitz A, Hwu P, Peng W, Dmitrovsky E, Liu X. Wei CH, et al. Among authors: chan kc. Sci Rep. 2023 Sep 9;13(1):14907. doi: 10.1038/s41598-023-41690-5. Sci Rep. 2023. PMID: 37689790 Free PMC article.
Objective monitoring tools for improved management of childhood asthma.
Au-Doung PLW, Chan JCH, Kui OYH, Ho MKY, Cheung YT, Lam JKW, Chan HK, Brannan J, Chan KCC, Li AM, Leung SSY. Au-Doung PLW, et al. Among authors: chan kcc. Respir Res. 2024 May 3;25(1):194. doi: 10.1186/s12931-024-02817-y. Respir Res. 2024. PMID: 38702779 Free PMC article. Review.
Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma.
Cai L, Zhu H, Mou Q, Wong PY, Lan L, Ng CWK, Lei P, Cheung MK, Wang D, Wong EWY, Lau EHL, Yeung ZWC, Lai R, Meehan K, Fung S, Chan KCA, Lui VWY, Cheng ASL, Yu J, Chan PKS, Chan JYK, Chen Z. Cai L, et al. Among authors: chan kca. NPJ Biofilms Microbiomes. 2024 Apr 8;10(1):39. doi: 10.1038/s41522-024-00511-x. NPJ Biofilms Microbiomes. 2024. PMID: 38589501 Free PMC article.
1,259 results