Chaikuad A - Search Results

1

Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.

Heering J, Jores N, Kilu W, Schallmayer E, Peelen E, Muehler A, Kohlhof H, Vitt D, Linhard V, Gande SL, Chaikuad A, Sreeramulu S, Schwalbe H, Merk D. Heering J, et al. Among authors: chaikuad a. ACS Chem Biol. 2022 Nov 18;17(11):3159-3168. doi: 10.1021/acschembio.2c00599. Epub 2022 Nov 1. ACS Chem Biol. 2022. PMID: 36318238

2

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.

Choi JY, Noguchi Y, Alburger JM, Bayle S, Chung E, Grant W, Chaikuad A, Knapp S, Duckett DR, Roush WR. Choi JY, et al. Among authors: chaikuad a. J Med Chem. 2023 Jun 8;66(11):7162-7178. doi: 10.1021/acs.jmedchem.2c01180. Epub 2023 May 19. J Med Chem. 2023. PMID: 37204207 Free PMC article.

3

UDP-glucose dehydrogenase: structure and function of a potential drug target.

Egger S, Chaikuad A, Kavanagh KL, Oppermann U, Nidetzky B. Egger S, et al. Among authors: chaikuad a. Biochem Soc Trans. 2010 Oct;38(5):1378-85. doi: 10.1042/BST0381378. Biochem Soc Trans. 2010. PMID: 20863317 Review.

4

Bisubstrate inhibitor approach for targeting mitotic kinase Haspin.

Kestav K, Lavogina D, Raidaru G, Chaikuad A, Knapp S, Uri A. Kestav K, et al. Among authors: chaikuad a. Bioconjug Chem. 2015 Feb 18;26(2):225-34. doi: 10.1021/bc500464r. Epub 2015 Jan 29. Bioconjug Chem. 2015. PMID: 25595038

5

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW. Chaikuad A, et al. BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14. BMC Struct Biol. 2012. PMID: 22720794 Free PMC article.

6

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

Horbelt D, Boergermann JH, Chaikuad A, Alfano I, Williams E, Lukonin I, Timmel T, Bullock AN, Knaus P. Horbelt D, et al. Among authors: chaikuad a. J Biol Chem. 2015 Feb 6;290(6):3390-404. doi: 10.1074/jbc.M114.604397. Epub 2014 Nov 3. J Biol Chem. 2015. PMID: 25368322 Free PMC article.

7

Design and Development of a Chemical Probe for Pseudokinase Ca²⁺/calmodulin-Dependent Ser/Thr Kinase.

Russ N, Schröder M, Berger BT, Mandel S, Aydogan Y, Mauer S, Pohl C, Drewry DH, Chaikuad A, Müller S, Knapp S. Russ N, et al. Among authors: chaikuad a. J Med Chem. 2021 Oct 14;64(19):14358-14376. doi: 10.1021/acs.jmedchem.1c00845. Epub 2021 Sep 20. J Med Chem. 2021. PMID: 34543009

8

Discovery of a PCAF Bromodomain Chemical Probe.

Moustakim M, Clark PG, Trulli L, Fuentes de Arriba AL, Ehebauer MT, Chaikuad A, Murphy EJ, Mendez-Johnson J, Daniels D, Hou CD, Lin YH, Walker JR, Hui R, Yang H, Dorrell L, Rogers CM, Monteiro OP, Fedorov O, Huber KV, Knapp S, Heer J, Dixon DJ, Brennan PE. Moustakim M, et al. Among authors: chaikuad a. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):827-831. doi: 10.1002/anie.201610816. Epub 2016 Dec 14. Angew Chem Int Ed Engl. 2017. PMID: 27966810 Free PMC article.

9

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN. Canning P, et al. Among authors: chaikuad a. J Biol Chem. 2013 Mar 15;288(11):7803-7814. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. J Biol Chem. 2013. PMID: 23349464 Free PMC article.

10

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.

Kerr G, Sheldon H, Chaikuad A, Alfano I, von Delft F, Bullock AN, Harris AL. Kerr G, et al. Among authors: chaikuad a. Angiogenesis. 2015 Apr;18(2):209-17. doi: 10.1007/s10456-014-9457-y. Epub 2015 Jan 4. Angiogenesis. 2015. PMID: 25557927 Free PMC article.

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