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The bone-degrading enzyme machinery: From multi-component understanding to the treatment of residues from the meat industry.
Comput Struct Biotechnol J. 2021 Nov 23;19:6328-6342. doi: 10.1016/j.csbj.2021.11.027. eCollection 2021.
Comput Struct Biotechnol J. 2021.
PMID: 34938409
Free PMC article.
Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase.
Cea-Rama I, Coscolín C, Katsonis P, Bargiela R, Golyshin PN, Lichtarge O, Ferrer M, Sanz-Aparicio J.
Cea-Rama I, et al.
Comput Struct Biotechnol J. 2021 Apr 18;19:2307-2317. doi: 10.1016/j.csbj.2021.04.041. eCollection 2021.
Comput Struct Biotechnol J. 2021.
PMID: 33995922
Free PMC article.
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Tuning the Properties of Natural Promiscuous Enzymes by Engineering Their Nano-environment.
Giunta CI, Cea-Rama I, Alonso S, Briand ML, Bargiela R, Coscolín C, Corvini PF, Ferrer M, Sanz-Aparicio J, Shahgaldian P.
Giunta CI, et al. Among authors: cea rama i.
ACS Nano. 2020 Dec 22;14(12):17652-17664. doi: 10.1021/acsnano.0c08716. Epub 2020 Dec 11.
ACS Nano. 2020.
PMID: 33306346
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Crystal structure of a family VIII β-lactamase fold hydrolase reveals the molecular mechanism for its broad substrate scope.
Cea-Rama I, Coscolín C, Gonzalez-Alfonso JL, Raj J, Vasiljević M, Plou FJ, Ferrer M, Sanz-Aparicio J.
Cea-Rama I, et al.
FEBS J. 2022 Nov;289(21):6714-6730. doi: 10.1111/febs.16554. Epub 2022 Jun 27.
FEBS J. 2022.
PMID: 35694902
Free PMC article.
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Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor.
Fernandez-Lopez L, Cea-Rama I, Alvarez-Malmagro J, Ressmann AK, Gonzalez-Alfonso JL, Coscolín C, Shahgaldian P, Plou FJ, Modregger J, Pita M, Sanz-Aparicio J, Ferrer M.
Fernandez-Lopez L, et al. Among authors: cea rama i.
Chem Commun (Camb). 2023 Aug 1;59(62):9469-9472. doi: 10.1039/d3cc01946b.
Chem Commun (Camb). 2023.
PMID: 37376994
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Increased Thermostability of an Engineered Flavin-Containing Monooxygenase to Remediate Trimethylamine in Fish Protein Hydrolysates.
Goris M, Cea-Rama I, Puntervoll P, Ree R, Almendral D, Sanz-Aparicio J, Ferrer M, Bjerga GEK.
Goris M, et al. Among authors: cea rama i.
Appl Environ Microbiol. 2023 Jun 28;89(6):e0039023. doi: 10.1128/aem.00390-23. Epub 2023 May 24.
Appl Environ Microbiol. 2023.
PMID: 37222584
Free PMC article.
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The Mobility of the Cap Domain Is Essential for the Substrate Promiscuity of a Family IV Esterase from Sorghum Rhizosphere Microbiome.
Distaso M, Cea-Rama I, Coscolín C, Chernikova TN, Tran H, Ferrer M, Sanz-Aparicio J, Golyshin PN.
Distaso M, et al. Among authors: cea rama i.
Appl Environ Microbiol. 2023 Jan 31;89(1):e0180722. doi: 10.1128/aem.01807-22. Epub 2023 Jan 5.
Appl Environ Microbiol. 2023.
PMID: 36602332
Free PMC article.
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