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Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Biagioli M, Marchianò S, di Giorgio C, Roselli R, Bordoni M, Bellini R, Fiorillo B, Sepe V, Catalanotti B, Cassiano C, Monti MC, Distrutti E, Zampella A, Fiorucci S. Biagioli M, et al. Among authors: catalanotti b. Hepatology. 2023 Jul 1;78(1):26-44. doi: 10.1002/hep.32787. Epub 2022 Oct 12. Hepatology. 2023. PMID: 36107019
Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain.
Carino A, Moraca F, Fiorillo B, Marchianò S, Sepe V, Biagioli M, Finamore C, Bozza S, Francisci D, Distrutti E, Catalanotti B, Zampella A, Fiorucci S. Carino A, et al. Among authors: catalanotti b. Front Chem. 2020 Oct 23;8:572885. doi: 10.3389/fchem.2020.572885. eCollection 2020. Front Chem. 2020. PMID: 33195060 Free PMC article.
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction.
Biagioli M, Marchianò S, Roselli R, Di Giorgio C, Bellini R, Bordoni M, Gidari A, Sabbatini S, Francisci D, Fiorillo B, Catalanotti B, Distrutti E, Carino A, Zampella A, Costantino G, Fiorucci S. Biagioli M, et al. Among authors: catalanotti b. Biochem Pharmacol. 2021 Jun;188:114564. doi: 10.1016/j.bcp.2021.114564. Epub 2021 Apr 17. Biochem Pharmacol. 2021. PMID: 33872570 Free PMC article.
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
Fiorillo B, Sepe V, Conflitti P, Roselli R, Biagioli M, Marchianò S, De Luca P, Baronissi G, Rapacciuolo P, Cassiano C, Catalanotti B, Zampella A, Limongelli V, Fiorucci S. Fiorillo B, et al. Among authors: catalanotti b. J Med Chem. 2021 Nov 25;64(22):16512-16529. doi: 10.1021/acs.jmedchem.1c01078. Epub 2021 Nov 12. J Med Chem. 2021. PMID: 34767347
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease.
Fiorucci S, Rapacciuolo P, Fiorillo B, Roselli R, Marchianò S, Di Giorgio C, Bordoni M, Bellini R, Cassiano C, Conflitti P, Catalanotti B, Limongelli V, Sepe V, Biagioli M, Zampella A. Fiorucci S, et al. Among authors: catalanotti b. Front Pharmacol. 2022 Apr 25;13:858137. doi: 10.3389/fphar.2022.858137. eCollection 2022. Front Pharmacol. 2022. PMID: 35559268 Free PMC article.
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
Di Giorgio C, Lupia A, Marchianò S, Bordoni M, Bellini R, Massa C, Urbani G, Roselli R, Moraca F, Sepe V, Catalanotti B, Morretta E, Monti MC, Biagioli M, Distrutti E, Zampella A, Fiorucci S. Di Giorgio C, et al. Among authors: catalanotti b. Cells. 2022 Nov 3;11(21):3482. doi: 10.3390/cells11213482. Cells. 2022. PMID: 36359879 Free PMC article.
Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.
Morgillo CM, Lupia A, Deplano A, Pirone L, Fiorillo B, Pedone E, Luque FJ, Onnis V, Moraca F, Catalanotti B. Morgillo CM, et al. Among authors: catalanotti b. Int J Mol Sci. 2022 Dec 7;23(24):15502. doi: 10.3390/ijms232415502. Int J Mol Sci. 2022. PMID: 36555144 Free PMC article.
56 results