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Prolonged dopamine D3 receptor stimulation promotes dopamine transporter ubiquitination and degradation through a PKC-dependent mechanism.
Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Barroso-Chinea P, Afonso-Oramas D, Febles-Casquero A, Cruz-Muros I, Salas-Hernandez J, Mesa-Infante V, Rodriguez-Nuñez J, Gonzalez-Hernandez T. Luis-Ravelo D, et al. Among authors: castro hernandez j. Pharmacol Res. 2021 Mar;165:105434. doi: 10.1016/j.phrs.2021.105434. Epub 2021 Jan 20. Pharmacol Res. 2021. PMID: 33484816
The dopamine transporter is differentially regulated after dopaminergic lesion.
Afonso-Oramas D, Cruz-Muros I, Barroso-Chinea P, Álvarez de la Rosa D, Castro-Hernández J, Salas-Hernández J, Giráldez T, González-Hernández T. Afonso-Oramas D, et al. Neurobiol Dis. 2010 Dec;40(3):518-30. doi: 10.1016/j.nbd.2010.07.012. Epub 2010 Aug 2. Neurobiol Dis. 2010. PMID: 20688165
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system.
Barroso-Chinea P, Cruz-Muros I, Afonso-Oramas D, Castro-Hernández J, Salas-Hernández J, Chtarto A, Luis-Ravelo D, Humbert-Claude M, Tenenbaum L, González-Hernández T. Barroso-Chinea P, et al. Among authors: castro hernandez j. Neurobiol Dis. 2016 Apr;88:44-54. doi: 10.1016/j.nbd.2016.01.002. Epub 2016 Jan 9. Neurobiol Dis. 2016. PMID: 26777664 Free article.
DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Barroso-Chinea P, Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Salas-Hernandez J, Rodriguez-Nuñez J, Febles-Casquero A, Cruz-Muros I, Afonso-Oramas D, Abreu-Gonzalez P, Moratalla R, Millan MJ, Gonzalez-Hernandez T. Barroso-Chinea P, et al. Among authors: castro hernandez j. Autophagy. 2020 Jul;16(7):1279-1295. doi: 10.1080/15548627.2019.1668606. Epub 2019 Oct 2. Autophagy. 2020. PMID: 31538542 Free PMC article.
Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease.
González-Hernández T, Cruz-Muros I, Afonso-Oramas D, Salas-Hernandez J, Castro-Hernandez J. González-Hernández T, et al. Front Neuroanat. 2010 Oct 20;4:140. doi: 10.3389/fnana.2010.00140. eCollection 2010. Front Neuroanat. 2010. PMID: 21079748 Free PMC article.
The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.
Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernández J, Dominguez J, Morty RE, Clauss W, González-Hernández T, Alvarez de la Rosa D, Giraldez T. Wesch D, et al. Am J Physiol Cell Physiol. 2010 Oct;299(4):C779-90. doi: 10.1152/ajpcell.00184.2010. Epub 2010 Jul 14. Am J Physiol Cell Physiol. 2010. PMID: 20631247 Free article.
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