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Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats.
Nicolau LAD, Carvalho NS, Pacífico DM, Lucetti LT, Aragão KS, Véras LMC, Souza MHLP, Leite JRSA, Medeiros JVR. Nicolau LAD, et al. Among authors: carvalho ns. Biomed Pharmacother. 2017 Mar;87:188-195. doi: 10.1016/j.biopha.2016.12.101. Epub 2017 Jan 2. Biomed Pharmacother. 2017. PMID: 28056423
Neutrophil-Derived COX-2 has a Key Role during Inflammatory Hyperalgesia.
Carvalho NS, Lemes JBP, Pagliusi M Jr, Machado ACDS, Malange KF, Pral LP, Fachi JL, Nishijima CM, Dos Santos GG, Tambeli CH, Sartori CR, Vinolo MAR, Parada CA. Carvalho NS, et al. Inflammation. 2022 Dec;45(6):2280-2293. doi: 10.1007/s10753-022-01690-5. Epub 2022 Jul 15. Inflammation. 2022. PMID: 35840810
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