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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW. Willard FS, et al. Among authors: capozzi me. JCI Insight. 2020 Sep 3;5(17):e140532. doi: 10.1172/jci.insight.140532. JCI Insight. 2020. PMID: 32730231 Free PMC article.
β Cell tone is defined by proglucagon peptides through cAMP signaling.
Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE. Capozzi ME, et al. JCI Insight. 2019 Mar 7;4(5):e126742. doi: 10.1172/jci.insight.126742. eCollection 2019 Mar 7. JCI Insight. 2019. PMID: 30720465 Free PMC article.
Glucagon lowers glycemia when β-cells are active.
Capozzi ME, Wait JB, Koech J, Gordon AN, Coch RW, Svendsen B, Finan B, D'Alessio DA, Campbell JE. Capozzi ME, et al. JCI Insight. 2019 Jul 23;5(16):e129954. doi: 10.1172/jci.insight.129954. JCI Insight. 2019. PMID: 31335319 Free PMC article.
Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.
Gray SM, Xin Y, Ross EC, Chazotte BM, Capozzi ME, El K, Svendsen B, Ravn P, Sloop KW, Tong J, Gromada J, Campbell JE, D'Alessio DA. Gray SM, et al. Among authors: capozzi me. J Biol Chem. 2020 Aug 14;295(33):11529-11541. doi: 10.1074/jbc.RA120.014368. Epub 2020 Jun 18. J Biol Chem. 2020. PMID: 32554468 Free PMC article.
41 results