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Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.
Faïon L, Djaout K, Frita R, Pintiala C, Cantrelle FX, Moune M, Vandeputte A, Bourbiaux K, Piveteau C, Herledan A, Biela A, Leroux F, Kremer L, Blaise M, Tanina A, Wintjens R, Hanoulle X, Déprez B, Willand N, Baulard AR, Flipo M. Faïon L, et al. Among authors: cantrelle fx. Eur J Med Chem. 2020 Aug 15;200:112440. doi: 10.1016/j.ejmech.2020.112440. Epub 2020 May 18. Eur J Med Chem. 2020. PMID: 32505086 Free article.
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: cantrelle fx. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
Proline Conformation in a Functional Tau Fragment.
Ahuja P, Cantrelle FX, Huvent I, Hanoulle X, Lopez J, Smet C, Wieruszeski JM, Landrieu I, Lippens G. Ahuja P, et al. Among authors: cantrelle fx. J Mol Biol. 2016 Jan 16;428(1):79-91. doi: 10.1016/j.jmb.2015.11.023. Epub 2015 Dec 2. J Mol Biol. 2016. PMID: 26655856
Interaction study between HCV NS5A-D2 and NS5B using 19F NMR.
Dujardin M, Cantrelle FX, Lippens G, Hanoulle X. Dujardin M, et al. Among authors: cantrelle fx. J Biomol NMR. 2018 Jan;70(1):67-76. doi: 10.1007/s10858-017-0159-9. Epub 2017 Dec 7. J Biomol NMR. 2018. PMID: 29218486
Backbone chemical shift assignments of human 14-3-3σ.
Neves JF, Landrieu I, Merzougui H, Boll E, Hanoulle X, Cantrelle FX. Neves JF, et al. Among authors: cantrelle fx. Biomol NMR Assign. 2019 Apr;13(1):103-107. doi: 10.1007/s12104-018-9860-1. Epub 2018 Oct 30. Biomol NMR Assign. 2019. PMID: 30377945
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, Mäkinen P, Marttinen M, Malki I, Chapuis J, Flaig A, Vreulx AC, Ciancia M, Amouyel P, Leroux F, Déprez B, Cantrelle FX, Maréchal D, Pradier L, Hiltunen M, Landrieu I, Kilinc D, Herault Y, Laporte J, Lambert JC. Sartori M, et al. Among authors: cantrelle fx. Acta Neuropathol. 2019 Oct;138(4):631-652. doi: 10.1007/s00401-019-02017-9. Epub 2019 May 7. Acta Neuropathol. 2019. PMID: 31065832 Free PMC article.
Set-up and screening of a fragment library targeting the 14-3-3 protein interface.
Valenti D, Neves JF, Cantrelle FX, Hristeva S, Lentini Santo D, Obšil T, Hanoulle X, Levy LM, Tzalis D, Landrieu I, Ottmann C. Valenti D, et al. Among authors: cantrelle fx. Medchemcomm. 2019 Jul 22;10(10):1796-1802. doi: 10.1039/c9md00215d. eCollection 2019 Oct 1. Medchemcomm. 2019. PMID: 31814953 Free PMC article.
65 results