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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Yun J, et al. Among authors: cantley lc. Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5. Science. 2015. PMID: 26541605 Free PMC article.
The phosphoinositide 3-kinase pathway.
Cantley LC. Cantley LC. Science. 2002 May 31;296(5573):1655-7. doi: 10.1126/science.296.5573.1655. Science. 2002. PMID: 12040186 Review.
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA. Engelman JA, et al. Among authors: cantley lc. Science. 2007 May 18;316(5827):1039-43. doi: 10.1126/science.1141478. Epub 2007 Apr 26. Science. 2007. PMID: 17463250
Biochemistry. PI3K charges ahead.
Lee JY, Engelman JA, Cantley LC. Lee JY, et al. Among authors: cantley lc. Science. 2007 Jul 13;317(5835):206-7. doi: 10.1126/science.1146073. Science. 2007. PMID: 17626872 No abstract available.
665 results