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Page 1
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS. Berlin M, et al. Among authors: cantley j. J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5. J Med Chem. 2024. PMID: 38180485
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C, Harbin A, Bortolon E, Chen X, Haskell R, Lin E, Yu SF, Del Rosario G, Chan E, Dunlap D, Koeppen H, Martin S, Merchant M, Grimmer M, Broccatelli F, Wang J, Pizzano J, Dragovich PS, Berlin M, Yauch RL. Cantley J, et al. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. Nat Commun. 2022. PMID: 36357397 Free PMC article.
Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs.
Kou P, Levy ES, Nguyen AD, Zhang D, Chen S, Cui Y, Zhang X, Broccatelli F, Pizzano J, Cantley J, Bortolon E, Rousseau E, Berlin M, Dragovich P, Sethuraman V. Kou P, et al. Among authors: cantley j. Pharmaceutics. 2023 Aug 8;15(8):2098. doi: 10.3390/pharmaceutics15082098. Pharmaceutics. 2023. PMID: 37631312 Free PMC article.
Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells.
Patibandla C, van Aalten L, Dinkova-Kostova AT, Honda T, Cuadrado A, Fernández-Ginés R, McNeilly AD, Hayes JD, Cantley J, Sutherland C. Patibandla C, et al. Among authors: cantley j. Redox Biol. 2024 May;71:103117. doi: 10.1016/j.redox.2024.103117. Epub 2024 Mar 7. Redox Biol. 2024. PMID: 38479223 Free PMC article.
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Sue N, Thai LM, Saito A, Boyer CK, Fordham AM, Yan C, Davenport A, Tao J, Bensellam M, Cantley J, Shi YC, Stephens SB, Imaizumi K, Biden TJ. Sue N, et al. Among authors: cantley j. Mol Metab. 2024 Jan;79:101845. doi: 10.1016/j.molmet.2023.101845. Epub 2023 Nov 25. Mol Metab. 2024. PMID: 38013154 Free PMC article.
Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.
Chen SY, Beretta M, Olzomer EM, Alexopoulos SJ, Shah DP, Byrne FL, Salamoun JM, Garcia CJ, Smith GC, Larance M, Philp A, Turner N, Santos WL, Cantley J, Hoehn KL. Chen SY, et al. Among authors: cantley j. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166908. doi: 10.1016/j.bbadis.2023.166908. Epub 2023 Oct 2. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37793464 Free article.
Metabolic regulation of glucagon secretion.
Armour SL, Stanley JE, Cantley J, Dean ED, Knudsen JG. Armour SL, et al. Among authors: cantley j. J Endocrinol. 2023 Sep 8;259(1):e230081. doi: 10.1530/JOE-23-0081. Print 2023 Sep 1. J Endocrinol. 2023. PMID: 37523232 Free PMC article.
74 results