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Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms.
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D'Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M. Uriarte M, et al. Among authors: cantel s. Mol Cell Endocrinol. 2021 Dec 1;538:111449. doi: 10.1016/j.mce.2021.111449. Epub 2021 Aug 31. Mol Cell Endocrinol. 2021. PMID: 34478806
Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Barrile F, M'Kadmi C, De Francesco PN, Cabral A, García Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banères JL, Marie J, Raingo J, Fehrentz JA, Perelló M. Barrile F, et al. Among authors: cantel s. Mol Cell Endocrinol. 2019 Dec 1;498:110573. doi: 10.1016/j.mce.2019.110573. Epub 2019 Sep 6. Mol Cell Endocrinol. 2019. PMID: 31499133
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M. Fernandez G, et al. Among authors: cantel s. Cell Mol Life Sci. 2022 May 4;79(5):277. doi: 10.1007/s00018-022-04302-5. Cell Mol Life Sci. 2022. PMID: 35504998
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin.
Péraldi-Roux S, Bayle M, M'Kadmi C, Damian M, Vaillé J, Fernandez G, Cornejo MP, Marie J, Banères JL, Ben Haj Salah K, Fehrentz JA, Cantel S, Perello M, Denoyelle S, Oiry C, Neasta J. Péraldi-Roux S, et al. Among authors: cantel s. Biochem Pharmacol. 2022 Aug;202:115114. doi: 10.1016/j.bcp.2022.115114. Epub 2022 May 31. Biochem Pharmacol. 2022. PMID: 35659880
Ghrelin proteolysis increases in plasma of men, but not women, with obesity.
Fittipaldi AS, Castrogiovanni D, Lufrano D, Saenz C, De Francesco PN, Lalonde T, Luyt LG, Cantel S, Fehrentz JA, Andreoli MF, Perello M. Fittipaldi AS, et al. Among authors: cantel s. Life Sci. 2023 Jan 15;313:121305. doi: 10.1016/j.lfs.2022.121305. Epub 2022 Dec 18. Life Sci. 2023. PMID: 36543283
Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation.
Barrile F, Cassano D, Fernandez G, De Francesco PN, Reynaldo M, Cantel S, Fehrentz JA, Donato J Jr, Schiöth HB, Zigman JM, Perello M. Barrile F, et al. Among authors: cantel s. Psychoneuroendocrinology. 2023 Oct;156:106333. doi: 10.1016/j.psyneuen.2023.106333. Epub 2023 Jul 13. Psychoneuroendocrinology. 2023. PMID: 37454647
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.
M'Kadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, Mary S, Denoyelle S, Dutertre S, Péraldi-Roux S, Neasta J, Oiry C, Banères JL, Marie J, Perello M, Fehrentz JA. M'Kadmi C, et al. Among authors: cantel s. J Med Chem. 2019 Jan 24;62(2):965-973. doi: 10.1021/acs.jmedchem.8b01644. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30543423
Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold.
Haj Salah KB, Maingot M, Blayo AL, M'Kadmi C, Damian M, Mary S, Cantel S, Neasta J, Oiry C, Péraldi-Roux S, Fernandez G, Romero GG, Perello M, Marie J, Banères JL, Fehrentz JA, Denoyelle S. Haj Salah KB, et al. Among authors: cantel s. J Med Chem. 2020 Oct 8;63(19):10796-10815. doi: 10.1021/acs.jmedchem.9b02122. Epub 2020 Sep 21. J Med Chem. 2020. PMID: 32882134
45 results