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Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.
Yoder RJ, Zhuang Q, Beck JM, Franjesevic A, Blanton TG, Sillart S, Secor T, Guerra L, Brown JD, Reid C, McElroy CA, Doğan Ekici Ö, Callam CS, Hadad CM. Yoder RJ, et al. Among authors: callam cs. ACS Med Chem Lett. 2017 May 8;8(6):622-627. doi: 10.1021/acsmedchemlett.7b00037. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626522 Free PMC article.
Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents.
Zhuang Q, Franjesevic AJ, Corrigan TS, Coldren WH, Dicken R, Sillart S, DeYong A, Yoshino N, Smith J, Fabry S, Fitzpatrick K, Blanton TG, Joseph J, Yoder RJ, McElroy CA, Ekici ÖD, Callam CS, Hadad CM. Zhuang Q, et al. Among authors: callam cs. J Med Chem. 2018 Aug 23;61(16):7034-7042. doi: 10.1021/acs.jmedchem.7b01620. Epub 2018 Jun 20. J Med Chem. 2018. PMID: 29870665
Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase.
Clay WK, Buck AK, He Y, Hernández Sánchez DN, Ward NA, Lear JM, Nguyen KQ, Clark BH, Sapia RJ, Lalisse RF, Sriraman A, Cadieux CL, McElroy CA, Callam CS, Hadad CM. Clay WK, et al. Among authors: callam cs. Chem Res Toxicol. 2024 Apr 15;37(4):643-657. doi: 10.1021/acs.chemrestox.4c00024. Epub 2024 Mar 31. Chem Res Toxicol. 2024. PMID: 38556765
4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase.
Lovins AR, Miller KA, Buck AK, Ensey DS, Homoelle RK, Murtha MC, Ward NA, Shanahan LA, Gutti G, Shriwas P, McElroy CA, Callam CS, Hadad CM. Lovins AR, et al. Among authors: callam cs. ACS Chem Neurosci. 2024 May 1;15(9):1813-1827. doi: 10.1021/acschemneuro.4c00011. Epub 2024 Apr 15. ACS Chem Neurosci. 2024. PMID: 38621296
19 results