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FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. Clifford BL, et al. Among authors: calkin ac. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. Cell Metab. 2021. PMID: 34270928 Free PMC article.
The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.
Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. Bond ST, et al. Among authors: calkin ac. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E293-E304. doi: 10.1152/ajpendo.00394.2018. Epub 2018 Dec 4. Am J Physiol Endocrinol Metab. 2019. PMID: 30512991 Free PMC article.
An integrative systems genetic analysis of mammalian lipid metabolism.
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. Parker BL, et al. Among authors: calkin ac. Nature. 2019 Mar;567(7747):187-193. doi: 10.1038/s41586-019-0984-y. Epub 2019 Feb 27. Nature. 2019. PMID: 30814737 Free PMC article.
Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner.
Zhuang A, Calkin AC, Lau S, Kiriazis H, Donner DG, Liu Y, Bond ST, Moody SC, Gould EAM, Colgan TD, Carmona SR, Inouye M, de Aguiar Vallim TQ, Tarling EJ, Quaife-Ryan GA, Hudson JE, Porrello ER, Gregorevic P, Gao XM, Du XJ, McMullen JR, Drew BG. Zhuang A, et al. Among authors: calkin ac. iScience. 2021 May 13;24(6):102537. doi: 10.1016/j.isci.2021.102537. eCollection 2021 Jun 25. iScience. 2021. PMID: 34142046 Free PMC article.
64 results