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Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: calixto jb. ChemMedChem. 2015 Dec;10(12):2014-26. doi: 10.1002/cmdc.201500360. Epub 2015 Oct 5. ChemMedChem. 2015. PMID: 26434977 Free PMC article.
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
Trevisan G, Rossato MF, Walker CI, Oliveira SM, Rosa F, Tonello R, Silva CR, Machado P, Boligon AA, Martins MA, Zanatta N, Bonacorso HG, Athayde ML, Rubin MA, Calixto JB, Ferreira J. Trevisan G, et al. Among authors: calixto jb. Neuropharmacology. 2013 Oct;73:261-73. doi: 10.1016/j.neuropharm.2013.06.011. Epub 2013 Jun 18. Neuropharmacology. 2013. PMID: 23791558
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: calixto jb. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.
412 results