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A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo A, Murabito A, Sala V, Pisano AR, Bertolini S, Gianotti A, Caci E, Montresor A, Premchandar A, Pirozzi F, Ren K, Della Sala A, Mergiotti M, Richter W, de Poel E, Matthey M, Caldrer S, Cardone RA, Civiletti F, Costamagna A, Quinney NL, Butnarasu C, Visentin S, Ruggiero MR, Baroni S, Crich SG, Ramel D, Laffargue M, Tocchetti CG, Levi R, Conti M, Lu XY, Melotti P, Sorio C, De Rose V, Facchinetti F, Fanelli V, Wenzel D, Fleischmann BK, Mall MA, Beekman J, Laudanna C, Gentzsch M, Lukacs GL, Pedemonte N, Hirsch E. Ghigo A, et al. Among authors: caci e. Sci Transl Med. 2022 Mar 30;14(638):eabl6328. doi: 10.1126/scitranslmed.abl6328. Epub 2022 Mar 30. Sci Transl Med. 2022. PMID: 35353541 Free PMC article.
Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.
Tomati V, Caci E, Ferrera L, Pesce E, Sondo E, Cholon DM, Quinney NL, Boyles SE, Armirotti A, Ravazzolo R, Galietta LJ, Gentzsch M, Pedemonte N. Tomati V, et al. Among authors: caci e. JCI Insight. 2018 Feb 8;3(3):e98699. doi: 10.1172/jci.insight.98699. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415893 Free PMC article.
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.
Pedemonte N, Tomati V, Sondo E, Caci E, Millo E, Armirotti A, Damonte G, Zegarra-Moran O, Galietta LJ. Pedemonte N, et al. Among authors: caci e. J Biol Chem. 2011 Apr 29;286(17):15215-26. doi: 10.1074/jbc.M110.184267. Epub 2011 Mar 7. J Biol Chem. 2011. PMID: 21383017 Free PMC article.
Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel.
Pedemonte N, Bertozzi F, Caci E, Sorana F, Di Fruscia P, Tomati V, Ferrera L, Rodríguez-Gimeno A, Berti F, Pesce E, Sondo E, Gianotti A, Scudieri P, Bandiera T, Galietta LJV. Pedemonte N, et al. Among authors: caci e. Sci Adv. 2020 Feb 21;6(8):eaay9669. doi: 10.1126/sciadv.aay9669. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128418 Free PMC article.
54 results