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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA. Cuyàs E, et al. Among authors: cabre n. Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8. Aging Cell. 2018. PMID: 29740925 Free PMC article.
Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.
Luciano-Mateo F, Hernández-Aguilera A, Cabre N, Camps J, Fernández-Arroyo S, Lopez-Miranda J, Menendez JA, Joven J. Luciano-Mateo F, et al. Among authors: cabre n. Nutrients. 2017 Feb 10;9(2):121. doi: 10.3390/nu9020121. Nutrients. 2017. PMID: 28208582 Free PMC article. Review.
Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study.
Riera-Borrull M, García-Heredia A, Fernández-Arroyo S, Hernández-Aguilera A, Cabré N, Cuyàs E, Luciano-Mateo F, Camps J, Menendez JA, Joven J. Riera-Borrull M, et al. Among authors: cabre n. Int J Mol Sci. 2017 Oct 28;18(11):2263. doi: 10.3390/ijms18112263. Int J Mol Sci. 2017. PMID: 29143783 Free PMC article.
Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging.
Luciano-Mateo F, Cabré N, Baiges-Gaya G, Fernández-Arroyo S, Hernández-Aguilera A, Elisabet Rodríguez-Tomàs E, Arenas M, Camps J, Menéndez JA, Joven J. Luciano-Mateo F, et al. Among authors: cabre n. Aging (Albany NY). 2020 Oct 26;12(20):20001-20023. doi: 10.18632/aging.104154. Epub 2020 Oct 26. Aging (Albany NY). 2020. PMID: 33104522 Free PMC article.
Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Luciano-Mateo F, Cabré N, Fernández-Arroyo S, Baiges-Gaya G, Hernández-Aguilera A, Rodríguez-Tomàs E, Mercado-Gómez M, Menendez JA, Camps J, Joven J. Luciano-Mateo F, et al. Among authors: cabre n. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1555-1566. doi: 10.1016/j.bbadis.2019.03.006. Epub 2019 Mar 21. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30905786 Free article.
Plasma metabolic alterations in patients with severe obesity and non-alcoholic steatohepatitis.
Cabré N, Luciano-Mateo F, Baiges-Gayà G, Fernández-Arroyo S, Rodríguez-Tomàs E, Hernández-Aguilera A, París M, Sabench F, Del Castillo D, López-Miranda J, Menéndez JA, Camps J, Joven J. Cabré N, et al. Aliment Pharmacol Ther. 2020 Feb;51(3):374-387. doi: 10.1111/apt.15606. Epub 2019 Dec 11. Aliment Pharmacol Ther. 2020. PMID: 31825539
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