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G protein-coupled receptor fusion proteins in drug discovery.
Milligan G, Feng GJ, Ward RJ, Sartania N, Ramsay D, McLean AJ, Carrillo JJ. Milligan G, et al. Curr Pharm Des. 2004;10(17):1989-2001. doi: 10.2174/1381612043384295. Curr Pharm Des. 2004. PMID: 15279540 Review.
Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4.
Bahia DS, Sartania N, Ward RJ, Cavalli A, Jones TL, Druey KM, Milligan G. Bahia DS, et al. J Neurochem. 2003 Jun;85(5):1289-98. doi: 10.1046/j.1471-4159.2003.01769.x. J Neurochem. 2003. PMID: 12753087 Free article.
Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.
Hiol A, Davey PC, Osterhout JL, Waheed AA, Fischer ER, Chen CK, Milligan G, Druey KM, Jones TL. Hiol A, et al. J Biol Chem. 2003 May 23;278(21):19301-8. doi: 10.1074/jbc.M210123200. Epub 2003 Mar 17. J Biol Chem. 2003. PMID: 12642593 Free article.
Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling.
Osterhout JL, Waheed AA, Hiol A, Ward RJ, Davey PC, Nini L, Wang J, Milligan G, Jones TL, Druey KM. Osterhout JL, et al. J Biol Chem. 2003 May 23;278(21):19309-16. doi: 10.1074/jbc.M210124200. Epub 2003 Mar 17. J Biol Chem. 2003. PMID: 12642592 Free article.