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Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification.
Maurya S, Yang W, Tamai M, Zhang Q, Erdmann-Gilmore P, Bystry A, Martins Rodrigues F, Valentine MC, Wong WH, Townsend R, Druley TE. Maurya S, et al. Among authors: bystry a. Epigenetics. 2022 Jan-Feb;17(2):220-238. doi: 10.1080/15592294.2021.1954780. Epub 2021 Jul 24. Epigenetics. 2022. PMID: 34304711 Free PMC article.
Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation.
Wong WH, Bhatt S, Trinkaus K, Pusic I, Elliott K, Mahajan N, Wan F, Switzer GE, Confer DL, DiPersio J, Pulsipher MA, Shah NN, Sees J, Bystry A, Blundell JR, Shaw BE, Druley TE. Wong WH, et al. Among authors: bystry a. Sci Transl Med. 2020 Jan 15;12(526):eaax6249. doi: 10.1126/scitranslmed.aax6249. Sci Transl Med. 2020. PMID: 31941826 Free PMC article.