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Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.
Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Brügger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Buzzi RM, et al. Mol Pharm. 2021 Aug 2;18(8):3158-3170. doi: 10.1021/acs.molpharmaceut.1c00433. Epub 2021 Jul 22. Mol Pharm. 2021. PMID: 34292741 Free article.
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.
Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ. Hugelshofer M, et al. Among authors: buzzi rm. J Clin Invest. 2019 Dec 2;129(12):5219-5235. doi: 10.1172/JCI130630. J Clin Invest. 2019. PMID: 31454333 Free PMC article.
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.
Pfefferlé M, Ingoglia G, Schaer CA, Yalamanoglu A, Buzzi R, Dubach IL, Tan G, López-Cano EY, Schulthess N, Hansen K, Humar R, Schaer DJ, Vallelian F. Pfefferlé M, et al. J Clin Invest. 2020 Oct 1;130(10):5576-5590. doi: 10.1172/JCI137282. J Clin Invest. 2020. PMID: 32663195 Free PMC article.
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.
Akeret K, Buzzi RM, Schaer CA, Thomson BR, Vallelian F, Wang S, Willms J, Sebök M, Held U, Deuel JW, Humar R, Regli L, Keller E, Hugelshofer M, Schaer DJ. Akeret K, et al. Among authors: buzzi rm. J Cereb Blood Flow Metab. 2021 Nov;41(11):3000-3015. doi: 10.1177/0271678X211020629. Epub 2021 Jun 8. J Cereb Blood Flow Metab. 2021. PMID: 34102922 Free PMC article.
Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease.
Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Buehler PW, et al. Among authors: buzzi rm. Free Radic Biol Med. 2021 Nov 1;175:95-107. doi: 10.1016/j.freeradbiomed.2021.08.238. Epub 2021 Aug 31. Free Radic Biol Med. 2021. PMID: 34478834 Free PMC article.
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
Vallelian F, Buzzi RM, Pfefferlé M, Yalamanoglu A, Dubach IL, Wassmer A, Gentinetta T, Hansen K, Humar R, Schulthess N, Schaer CA, Schaer DJ. Vallelian F, et al. Among authors: buzzi rm. Cell Death Differ. 2022 Aug;29(8):1450-1465. doi: 10.1038/s41418-022-00932-1. Epub 2022 Jan 14. Cell Death Differ. 2022. PMID: 35031770 Free PMC article.
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