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Hurdles in therapy with regulatory T cells.
Trzonkowski P, Bacchetta R, Battaglia M, Berglund D, Bohnenkamp HR, ten Brinke A, Bushell A, Cools N, Geissler EK, Gregori S, Marieke van Ham S, Hilkens C, Hutchinson JA, Lombardi G, Madrigal JA, Marek-Trzonkowska N, Martinez-Caceres EM, Roncarolo MG, Sanchez-Ramon S, Saudemont A, Sawitzki B. Trzonkowski P, et al. Among authors: bushell a. Sci Transl Med. 2015 Sep 9;7(304):304ps18. doi: 10.1126/scitranslmed.aaa7721. Sci Transl Med. 2015. PMID: 26355029 Review.
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK. Sawitzki B, et al. Among authors: bushell a. Lancet. 2020 May 23;395(10237):1627-1639. doi: 10.1016/S0140-6736(20)30167-7. Lancet. 2020. PMID: 32446407 Free PMC article.
Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients.
Harden PN, Game DS, Sawitzki B, Van der Net JB, Hester J, Bushell A, Issa F, Brook MO, Alzhrani A, Schlickeiser S, Scotta C, Petchey W, Streitz M, Blancho G, Tang Q, Markmann J, Lechler RI, Roberts ISD, Friend PJ, Hilton R, Geissler EK, Wood KJ, Lombardi G. Harden PN, et al. Among authors: bushell a. Am J Transplant. 2021 Apr;21(4):1603-1611. doi: 10.1111/ajt.16395. Epub 2021 Feb 2. Am J Transplant. 2021. PMID: 33171020 Free PMC article. Clinical Trial.
A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.
Fraser H, Safinia N, Grageda N, Thirkell S, Lowe K, Fry LJ, Scottá C, Hope A, Fisher C, Hilton R, Game D, Harden P, Bushell A, Wood K, Lechler RI, Lombardi G. Fraser H, et al. Among authors: bushell a. Mol Ther Methods Clin Dev. 2018 Jan 31;8:198-209. doi: 10.1016/j.omtm.2018.01.006. eCollection 2018 Mar 16. Mol Ther Methods Clin Dev. 2018. PMID: 29552576 Free PMC article.
Interferon gamma: friend or foe?
Wood KJ, Feng G, Wei B, Sawitzki B, Bushell AR. Wood KJ, et al. Transplantation. 2007 Jul 15;84(1 Suppl):S4-5. doi: 10.1097/01.tp.0000269115.60728.b1. Transplantation. 2007. PMID: 17632413
Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients.
Brook MO, Hester J, Petchey W, Rombach I, Dutton S, Bottomley MJ, Black J, Abdul-Wahab S, Bushell A, Lombardi G, Wood K, Friend P, Harden P, Issa F. Brook MO, et al. Among authors: bushell a. BMJ Open. 2022 Apr 15;12(4):e061864. doi: 10.1136/bmjopen-2022-061864. BMJ Open. 2022. PMID: 35428650 Free PMC article.
121 results