Burkholder NT - Search Results

1

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

Zhao S, Lu J, Pan B, Fan H, Byrum SD, Xu C, Kim A, Guo Y, Kanchi KL, Gong W, Sun T, Storey AJ, Burkholder NT, Mackintosh SG, Kuhlers PC, Edmondson RD, Strahl BD, Diao Y, Tackett AJ, Raab JR, Cai L, Song J, Wang GG. Zhao S, et al. Among authors: burkholder nt. Nature. 2023 Nov;623(7987):633-642. doi: 10.1038/s41586-023-06688-z. Epub 2023 Nov 8. Nature. 2023. PMID: 37938770 Free PMC article.

2

The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation.

Petell CJ, Burkholder NT, Ruiz PA, Skela J, Foreman JR, Southwell LE, Temple BR, Krajewski K, Strahl BD. Petell CJ, et al. Among authors: burkholder nt. J Biol Chem. 2023 Aug;299(8):104996. doi: 10.1016/j.jbc.2023.104996. Epub 2023 Jun 30. J Biol Chem. 2023. PMID: 37394010 Free PMC article.

3

Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.

Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B, Lamb C, Tanno Y, Siddiqui MY, Ashoura N, Coma S, Zhang XM, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, Georgiou G. Blazeck J, et al. Among authors: burkholder nt. Nat Catal. 2022 Oct;5(10):952-967. doi: 10.1038/s41929-022-00856-6. Epub 2022 Oct 19. Nat Catal. 2022. PMID: 36465553 Free PMC article.

4

Using fungible biosensors to evolve improved alkaloid biosyntheses.

d'Oelsnitz S, Kim W, Burkholder NT, Javanmardi K, Thyer R, Zhang Y, Alper HS, Ellington AD. d'Oelsnitz S, et al. Among authors: burkholder nt. Nat Chem Biol. 2022 Sep;18(9):981-989. doi: 10.1038/s41589-022-01072-w. Epub 2022 Jul 7. Nat Chem Biol. 2022. PMID: 35799063

5

The ZZ domain of HERC2 is a receptor of arginylated substrates.

Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. Tencer AH, et al. Among authors: burkholder nt. Sci Rep. 2022 Apr 11;12(1):6063. doi: 10.1038/s41598-022-10119-w. Sci Rep. 2022. PMID: 35411094 Free PMC article.

6

Mapping RNAPII CTD Phosphorylation Reveals That the Identity and Modification of Seventh Heptad Residues Direct Tyr1 Phosphorylation.

Burkholder NT, Sipe SN, Escobar EE, Venkatramani M, Irani S, Yang W, Wu H, Matthews WM, Brodbelt JS, Zhang Y. Burkholder NT, et al. ACS Chem Biol. 2019 Oct 18;14(10):2264-2275. doi: 10.1021/acschembio.9b00610. Epub 2019 Oct 7. ACS Chem Biol. 2019. PMID: 31553563 Free PMC article.

7

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb.

Mayfield JE, Irani S, Escobar EE, Zhang Z, Burkholder NT, Robinson MR, Mehaffey MR, Sipe SN, Yang W, Prescott NA, Kathuria KR, Liu Z, Brodbelt JS, Zhang Y. Mayfield JE, et al. Among authors: burkholder nt. Elife. 2019 Aug 6;8:e48725. doi: 10.7554/eLife.48725. Elife. 2019. PMID: 31385803 Free PMC article.

8

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Irani S, Sipe SN, Yang W, Burkholder NT, Lin B, Sim K, Matthews WL, Brodbelt JS, Zhang Y. Irani S, et al. Among authors: burkholder nt. J Biol Chem. 2019 May 24;294(21):8592-8605. doi: 10.1074/jbc.RA119.007697. Epub 2019 Apr 10. J Biol Chem. 2019. PMID: 30971428 Free PMC article.

9

Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).

Burkholder NT, Mayfield JE, Yu X, Irani S, Arce DK, Jiang F, Matthews WL, Xue Y, Zhang YJ. Burkholder NT, et al. J Biol Chem. 2018 Oct 26;293(43):16851-16861. doi: 10.1074/jbc.RA118.004722. Epub 2018 Sep 14. J Biol Chem. 2018. PMID: 30217818 Free PMC article.

10

Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity.

Burkholder NT, Medellin B, Irani S, Matthews W, Showalter SA, Zhang YJ. Burkholder NT, et al. Methods Enzymol. 2018;607:269-297. doi: 10.1016/bs.mie.2018.04.020. Epub 2018 Jun 23. Methods Enzymol. 2018. PMID: 30149861 Free PMC article.

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