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Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
Vilasi S, Carrotta R, Mangione MR, Campanella C, Librizzi F, Randazzo L, Martorana V, Marino Gammazza A, Ortore MG, Vilasi A, Pocsfalvi G, Burgio G, Corona D, Palumbo Piccionello A, Zummo G, Bulone D, Conway de Macario E, Macario AJ, San Biagio PL, Cappello F. Vilasi S, et al. Among authors: burgio g. PLoS One. 2014 May 15;9(5):e97657. doi: 10.1371/journal.pone.0097657. eCollection 2014. PLoS One. 2014. PMID: 24830947 Free PMC article.
Hsp60 is actively secreted by human tumor cells.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, Cappello F. Merendino AM, et al. Among authors: burgio g. PLoS One. 2010 Feb 16;5(2):e9247. doi: 10.1371/journal.pone.0009247. PLoS One. 2010. PMID: 20169074 Free PMC article.
The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities.
Campanella C, Bucchieri F, Merendino AM, Fucarino A, Burgio G, Corona DF, Barbieri G, David S, Farina F, Zummo G, de Macario EC, Macario AJ, Cappello F. Campanella C, et al. Among authors: burgio g. PLoS One. 2012;7(7):e42008. doi: 10.1371/journal.pone.0042008. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848686 Free PMC article.
463 results