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An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.
Kimura T, Bosakova M, Nonaka Y, Hruba E, Yasuda K, Futakawa S, Kubota T, Fafilek B, Gregor T, Abraham SP, Gomolkova R, Belaskova S, Pesl M, Csukasi F, Duran I, Fujiwara M, Kavkova M, Zikmund T, Kaiser J, Buchtova M, Krakow D, Nakamura Y, Ozono K, Krejci P. Kimura T, et al. Among authors: buchtova m. Sci Transl Med. 2021 May 5;13(592):eaba4226. doi: 10.1126/scitranslmed.aba4226. Sci Transl Med. 2021. PMID: 33952673
Effect of FGFR inhibitors on chicken limb development.
Horakova D, Cela P, Krejci P, Balek L, Moravcova Balkova S, Matalova E, Buchtova M. Horakova D, et al. Among authors: buchtova m. Dev Growth Differ. 2014 Oct;56(8):555-72. doi: 10.1111/dgd.12156. Epub 2014 Oct 3. Dev Growth Differ. 2014. PMID: 25280231
Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.
Buchtova M, Oralova V, Aklian A, Masek J, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, Bryja V, Krejci P. Buchtova M, et al. Biochim Biophys Acta. 2015 May;1852(5):839-50. doi: 10.1016/j.bbadis.2014.12.020. Epub 2015 Jan 2. Biochim Biophys Acta. 2015. PMID: 25558817 Free article.
Instability restricts signaling of multiple fibroblast growth factors.
Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P. Buchtova M, et al. Cell Mol Life Sci. 2015 Jun;72(12):2445-59. doi: 10.1007/s00018-015-1856-8. Epub 2015 Feb 18. Cell Mol Life Sci. 2015. PMID: 25854632
Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.
Gudernova I, Vesela I, Balek L, Buchtova M, Dosedelova H, Kunova M, Pivnicka J, Jelinkova I, Roubalova L, Kozubik A, Krejci P. Gudernova I, et al. Among authors: buchtova m. Hum Mol Genet. 2016 Jan 1;25(1):9-23. doi: 10.1093/hmg/ddv441. Epub 2015 Oct 22. Hum Mol Genet. 2016. PMID: 26494904
Statins do not inhibit the FGFR signaling in chondrocytes.
Fafilek B, Hampl M, Ricankova N, Vesela I, Balek L, Kunova Bosakova M, Gudernova I, Varecha M, Buchtova M, Krejci P. Fafilek B, et al. Among authors: buchtova m. Osteoarthritis Cartilage. 2017 Sep;25(9):1522-1530. doi: 10.1016/j.joca.2017.05.014. Epub 2017 Jun 3. Osteoarthritis Cartilage. 2017. PMID: 28583899 Free article.
Role of Primary Cilia in Odontogenesis.
Hampl M, Cela P, Szabo-Rogers HL, Kunova Bosakova M, Dosedelova H, Krejci P, Buchtova M. Hampl M, et al. Among authors: buchtova m. J Dent Res. 2017 Aug;96(9):965-974. doi: 10.1177/0022034517713688. Epub 2017 Jun 12. J Dent Res. 2017. PMID: 28605602 Free PMC article. Review.
ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3.
Balek L, Gudernova I, Vesela I, Hampl M, Oralova V, Kunova Bosakova M, Varecha M, Nemec P, Hall T, Abbadessa G, Hatch N, Buchtova M, Krejci P. Balek L, et al. Among authors: buchtova m. Bone. 2017 Dec;105:57-66. doi: 10.1016/j.bone.2017.08.016. Epub 2017 Aug 18. Bone. 2017. PMID: 28826843
84 results