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Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters.
Levy M, Chen JW, Kaiser JA, Park HS, Liu X, Yang L, Santos C, Buchholz UJ, Le Nouën C. Levy M, et al. Among authors: buchholz uj. PLoS Pathog. 2024 May 13;20(5):e1012198. doi: 10.1371/journal.ppat.1012198. Online ahead of print. PLoS Pathog. 2024. PMID: 38739647 Free article.
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
Kaiser JA, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers LRH, Herbert R, Moore IN, Wilder-Kofie T, Moore R, Walker A, Yang L, Munir S, Teng IT, Kwong PD, Dowdell K, Nguyen H, Kim J, Cohen JI, Johnson RF, Garza NL, Via LE, Barber DL, Buchholz UJ, Le Nouën C. Kaiser JA, et al. Among authors: buchholz uj. Nat Commun. 2024 Apr 26;15(1):3553. doi: 10.1038/s41467-024-47784-6. Nat Commun. 2024. PMID: 38670948 Free PMC article.
Mutations in the F protein of the live-attenuated respiratory syncytial virus vaccine candidate ΔNS2/Δ1313/I1314L increase the stability of infectivity and content of prefusion F protein.
Alamares-Sapuay J, Kishko M, Lai C, Parrington M, Delagrave S, Herbert R, Castens A, Swerczek J, Luongo C, Yang L, Collins PL, Buchholz UJ, Zhang L. Alamares-Sapuay J, et al. Among authors: buchholz uj. PLoS One. 2024 Apr 9;19(4):e0301773. doi: 10.1371/journal.pone.0301773. eCollection 2024. PLoS One. 2024. PMID: 38593167 Free PMC article.
Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques.
Kaiser JA, Liu X, Luongo C, Matsuoka Y, Santos C, Yang L, Herbert R, Castens A, Dorward DW, Johnson RF, Park HS, Afroz S, Munir S, Le Nouën C, Buchholz UJ. Kaiser JA, et al. Among authors: buchholz uj. iScience. 2023 Nov 22;26(12):108490. doi: 10.1016/j.isci.2023.108490. eCollection 2023 Dec 15. iScience. 2023. PMID: 38144450 Free PMC article.
Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus.
Ou L, Chen SJ, Teng IT, Yang L, Zhang B, Zhou T, Biju A, Cheng C, Kong WP, Morano NC, Stancofski ED, Todd JP, Tsybovsky Y, Wang S, Zheng CY, Mascola JR, Shapiro L, Woodward RA, Buchholz UJ, Kwong PD. Ou L, et al. Among authors: buchholz uj. PLoS Pathog. 2023 Sep 22;19(9):e1011584. doi: 10.1371/journal.ppat.1011584. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37738240 Free PMC article.
Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).
Kuhn JH, Abe J, Adkins S, Alkhovsky SV, Avšič-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Kumar Baranwal V, Beer M, Bejerman N, Bergeron É, Biedenkopf N, Blair CD, Blasdell KR, Blouin AG, Bradfute SB, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Büttner C, Calisher CH, Cao M, Casas I, Chandran K, Charrel RN, Kumar Chaturvedi K, Chooi KM, Crane A, Dal Bó E, Carlos de la Torre J, de Souza WM, de Swart RL, Debat H, Dheilly NM, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Drexler JF, Duprex WP, Dürrwald R, Easton AJ, Elbeaino T, Ergünay K, Feng G, Firth AE, Fooks AR, Formenty PBH, Freitas-Astúa J, Gago-Zachert S, Laura García M, García-Sastre A, Garrison AR, Gaskin TR, Gong W, Gonzalez JJ, de Bellocq J, Griffiths A, Groschup MH, Günther I, Günther S, Hammond J, Hasegawa Y, Hayashi K, Hepojoki J, Higgins CM, Hongō S, Horie M, Hughes HR, Hume AJ, Hyndman TH, Ikeda K, Jiāng D, Jonson GB, Junglen S, Klempa B, Klingström J, Kondō H, Koonin EV, Krupovic M, Kubota K, Kurath G, Laenen L, Lambert AJ, Lǐ J, Li JM, Liu R, Lukashevich IS, MacDiarmid RM, Maes P, Marklewitz M, Marshall SH, Marzano SL, McCauley JW, Mirazimi A, Mühlberger E, Nabeshi… See abstract for full author list ➔ Kuhn JH, et al. Among authors: buchholz uj. J Gen Virol. 2023 Aug;104(8):001864. doi: 10.1099/jgv.0.001864. J Gen Virol. 2023. PMID: 37622664 Free PMC article.
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.
Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Le Nouën C. Liu X, et al. Among authors: buchholz uj. PLoS Pathog. 2023 Jun 23;19(6):e1011057. doi: 10.1371/journal.ppat.1011057. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352333 Free PMC article.
Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities-workshop report.
Knisely JM, Buyon LE, Mandt R, Farkas R, Balasingam S, Bok K, Buchholz UJ, D'Souza MP, Gordon JL, King DFL, Le TT, Leitner WW, Seder RA, Togias A, Tollefsen S, Vaughn DW, Wolfe DN, Taylor KL, Fauci AS. Knisely JM, et al. Among authors: buchholz uj. NPJ Vaccines. 2023 Apr 12;8(1):53. doi: 10.1038/s41541-023-00654-6. NPJ Vaccines. 2023. PMID: 37045860 Free PMC article.
110 results