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SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S. Damonte P, et al. Among authors: bruzzone s. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19. Bioorg Med Chem. 2017. PMID: 28958848
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.
Basile G, Taglialatela-Scafati O, Damonte G, Armirotti A, Bruzzone S, Guida L, Franco L, Usai C, Fattorusso E, De Flora A, Zocchi E. Basile G, et al. Among authors: bruzzone s. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14509-14. doi: 10.1073/pnas.0503691102. Epub 2005 Sep 19. Proc Natl Acad Sci U S A. 2005. PMID: 16172408 Free PMC article.
LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
Sturla L, Fresia C, Guida L, Bruzzone S, Scarfì S, Usai C, Fruscione F, Magnone M, Millo E, Basile G, Grozio A, Jacchetti E, Allegretti M, De Flora A, Zocchi E. Sturla L, et al. Among authors: bruzzone s. J Biol Chem. 2009 Oct 9;284(41):28045-28057. doi: 10.1074/jbc.M109.035329. Epub 2009 Aug 10. J Biol Chem. 2009. PMID: 19667068 Free PMC article.
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F, Mostoslavsky R, Uccelli A, Nencioni A. Bruzzone S, et al. PLoS One. 2009 Nov 19;4(11):e7897. doi: 10.1371/journal.pone.0007897. PLoS One. 2009. PMID: 19936064 Free PMC article.
200 results