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Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.
Peikert K, Federti E, Matte A, Constantin G, Pietronigro EC, Fabene PF, Defilippi P, Turco E, Del Gallo F, Pucci P, Amoresano A, Illiano A, Cozzolino F, Monti M, Garello F, Terreno E, Alper SL, Glaß H, Pelzl L, Akgün K, Ziemssen T, Ordemann R, Lang F, Brunati AM, Tibaldi E, Andolfo I, Iolascon A, Bertini G, Buffelli M, Zancanaro C, Lorenzetto E, Siciliano A, Bonifacio M, Danek A, Walker RH, Hermann A, De Franceschi L. Peikert K, et al. Among authors: brunati am. Acta Neuropathol Commun. 2021 May 3;9(1):81. doi: 10.1186/s40478-021-01181-y. Acta Neuropathol Commun. 2021. PMID: 33941276 Free PMC article.
Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity.
De Franceschi L, Tomelleri C, Matte A, Brunati AM, Bovee-Geurts PH, Bertoldi M, Lasonder E, Tibaldi E, Danek A, Walker RH, Jung HH, Bader B, Siciliano A, Ferru E, Mohandas N, Bosman GJ. De Franceschi L, et al. Among authors: brunati am. Blood. 2011 Nov 17;118(20):5652-63. doi: 10.1182/blood-2011-05-355339. Epub 2011 Sep 27. Blood. 2011. PMID: 21951684 Free PMC article.
A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.
Lupo F, Tibaldi E, Matte A, Sharma AK, Brunati AM, Alper SL, Zancanaro C, Benati D, Siciliano A, Bertoldi M, Zonta F, Storch A, Walker RH, Danek A, Bader B, Hermann A, De Franceschi L. Lupo F, et al. Among authors: brunati am. Blood. 2016 Dec 22;128(25):2976-2987. doi: 10.1182/blood-2016-07-727321. Epub 2016 Oct 14. Blood. 2016. PMID: 27742708 Free PMC article.
Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells.
Mattè A, Federti E, Tibaldi E, Di Paolo ML, Bisello G, Bertoldi M, Carpentieri A, Pucci P, Iatchencko I, Wilson AB, Riccardi V, Siciliano A, Turrini F, Kim DW, Choi SY, Brunati AM, De Franceschi L. Mattè A, et al. Among authors: brunati am. Antioxidants (Basel). 2021 Feb 1;10(2):206. doi: 10.3390/antiox10020206. Antioxidants (Basel). 2021. PMID: 33535382 Free PMC article.
HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.
Frezzato F, Gattazzo C, Martini V, Trimarco V, Teramo A, Carraro S, Cabrelle A, Ave E, Facco M, Zambello R, Tibaldi E, Brunati AM, Semenzato G, Trentin L. Frezzato F, et al. Among authors: brunati am. PLoS One. 2012;7(6):e39902. doi: 10.1371/journal.pone.0039902. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768161 Free PMC article.
Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase.
Mattè A, Lupo F, Tibaldi E, Di Paolo ML, Federti E, Carpentieri A, Pucci P, Brunati AM, Cesaro L, Turrini F, Gomez Manzo S, Choi SY, Marcial Quino J, Kim DW, Pantaleo A, Xiuli A, Iatcenko I, Cappellini MD, Forni GL, De Franceschi L. Mattè A, et al. Among authors: brunati am. Redox Biol. 2020 Sep;36:101639. doi: 10.1016/j.redox.2020.101639. Epub 2020 Jul 11. Redox Biol. 2020. PMID: 32863204 Free PMC article.
134 results