Brownell AL - Search Results

1

Design, Synthesis, and Characterization of [¹⁸F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2.

Yuan G, Dhaynaut M, Guehl NJ, Afshar S, Huynh D, Moon SH, Iyengar SM, Jain MK, Pickett JE, Kang HJ, Ondrechen MJ, El Fakhri G, Normandin MD, Brownell AL. Yuan G, et al. Among authors: brownell al. J Med Chem. 2022 Jul 28;65(14):9939-9954. doi: 10.1021/acs.jmedchem.2c00593. Epub 2022 Jul 8. J Med Chem. 2022. PMID: 35802702 Free PMC article.

2

Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors.

Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Yu M, et al. Among authors: brownell al. Nucl Med Biol. 2005 Aug;32(6):631-40. doi: 10.1016/j.nucmedbio.2005.05.004. Nucl Med Biol. 2005. PMID: 16026710

3

Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.

Wang JQ, Tueckmantel W, Zhu A, Pellegrino D, Brownell AL. Wang JQ, et al. Among authors: brownell al. Synapse. 2007 Dec;61(12):951-61. doi: 10.1002/syn.20445. Synapse. 2007. PMID: 17787003

4

Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo.

Wang JQ, Zhang Z, Kuruppu D, Brownell AL. Wang JQ, et al. Among authors: brownell al. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1958-62. doi: 10.1016/j.bmcl.2012.01.039. Epub 2012 Jan 21. Bioorg Med Chem Lett. 2012. PMID: 22318160 Free PMC article.

5

Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4).

Kil KE, Zhang Z, Jokivarsi K, Gong C, Choi JK, Kura S, Brownell AL. Kil KE, et al. Among authors: brownell al. Bioorg Med Chem. 2013 Oct 1;21(19):5955-62. doi: 10.1016/j.bmc.2013.07.046. Epub 2013 Aug 2. Bioorg Med Chem. 2013. PMID: 23978356 Free PMC article.

6

Development of [(123)I]IPEB and [(123)I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5.

Kil KE, Zhu A, Zhang Z, Choi JK, Kura S, Gong C, Brownell AL. Kil KE, et al. Among authors: brownell al. ACS Med Chem Lett. 2014 Apr 6;5(6):652-6. doi: 10.1021/ml500007z. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944738 Free PMC article.

7

Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).

Kil KE, Poutiainen P, Zhang Z, Zhu A, Choi JK, Jokivarsi K, Brownell AL. Kil KE, et al. Among authors: brownell al. J Med Chem. 2014 Nov 13;57(21):9130-8. doi: 10.1021/jm501245b. Epub 2014 Oct 27. J Med Chem. 2014. PMID: 25330258 Free PMC article.

8

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.

Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Zhang Z, et al. Among authors: brownell al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3956-60. doi: 10.1016/j.bmcl.2015.07.031. Epub 2015 Jul 17. Bioorg Med Chem Lett. 2015. PMID: 26231155 Free PMC article.

9

Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4.

Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Kil KE, et al. Among authors: brownell al. Bioorg Med Chem Lett. 2016 Jan 1;26(1):133-9. doi: 10.1016/j.bmcl.2015.11.015. Epub 2015 Nov 10. Bioorg Med Chem Lett. 2016. PMID: 26602273 Free PMC article.

10

Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d₂)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain.

Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Wang J, et al. Among authors: brownell al. J Med Chem. 2020 Mar 26;63(6):3381-3389. doi: 10.1021/acs.jmedchem.0c00201. Epub 2020 Mar 4. J Med Chem. 2020. PMID: 32081008 Free PMC article.

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