Brown P - Search Results

1

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections.

Brown P, Dawson MJ. Brown P, et al. J Antibiot (Tokyo). 2017 Apr;70(4):386-394. doi: 10.1038/ja.2016.146. Epub 2017 Jan 11. J Antibiot (Tokyo). 2017. PMID: 28074057 Review.

2

Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.

Brown P, Abdulle O, Boakes S, Duperchy E, Moss S, Simonovic M, Stanway S, Wilson A, Dawson MJ. Brown P, et al. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127163. doi: 10.1016/j.bmcl.2020.127163. Epub 2020 Mar 30. Bioorg Med Chem Lett. 2020. PMID: 32273214 Free PMC article.

3

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.

Brown P, Abbott E, Abdulle O, Boakes S, Coleman S, Divall N, Duperchy E, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ. Brown P, et al. ACS Infect Dis. 2019 Oct 11;5(10):1645-1656. doi: 10.1021/acsinfecdis.9b00217. Epub 2019 Sep 24. ACS Infect Dis. 2019. PMID: 31525992 Free PMC article.

4

Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.

Brown P, Abdulle O, Boakes S, Divall N, Duperchy E, Ganeshwaran S, Lester R, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ. Brown P, et al. ACS Infect Dis. 2021 Apr 9;7(4):894-905. doi: 10.1021/acsinfecdis.0c00917. Epub 2021 Mar 10. ACS Infect Dis. 2021. PMID: 33688718 Free PMC article.

5

A perspective on the next generation of antibacterial agents derived by manipulation of natural products.

Brown P, Dawson MJ. Brown P, et al. Prog Med Chem. 2015;54:135-84. doi: 10.1016/bs.pmch.2014.10.001. Epub 2014 Dec 1. Prog Med Chem. 2015. PMID: 25727704 Review.

6

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ. Jarvest RL, et al. Among authors: brown mj, brown p. Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8. doi: 10.1016/s0960-894x(02)01027-2. Bioorg Med Chem Lett. 2003. PMID: 12639554

7

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S. Jarvest RL, et al. Among authors: brown p. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8. doi: 10.1016/s0960-894x(03)00093-3. Bioorg Med Chem Lett. 2003. PMID: 12657260

8

The chemistry of Pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles.

Brown P, Davies DT, O'Hanlon PJ, Wilson JM. Brown P, et al. J Med Chem. 1996 Jan 19;39(2):446-57. doi: 10.1021/jm9503862. J Med Chem. 1996. PMID: 8558513

9

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Among authors: brown mj, brown p. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702

10

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

Miles TJ, Hennessy AJ, Bax B, Brooks G, Brown BS, Brown P, Cailleau N, Chen D, Dabbs S, Davies DT, Esken JM, Giordano I, Hoover JL, Jones GE, Kusalakumari Sukmar SK, Markwell RE, Minthorn EA, Rittenhouse S, Gwynn MN, Pearson ND. Miles TJ, et al. Among authors: brown bs, brown p. Bioorg Med Chem Lett. 2016 May 15;26(10):2464-2469. doi: 10.1016/j.bmcl.2016.03.106. Epub 2016 Mar 31. Bioorg Med Chem Lett. 2016. PMID: 27055939

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