Brown P - Search Results

1

A perspective on the next generation of antibacterial agents derived by manipulation of natural products.

Brown P, Dawson MJ. Brown P, et al. Prog Med Chem. 2015;54:135-84. doi: 10.1016/bs.pmch.2014.10.001. Epub 2014 Dec 1. Prog Med Chem. 2015. PMID: 25727704 Review.

2

Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.

Brown P, Abdulle O, Boakes S, Duperchy E, Moss S, Simonovic M, Stanway S, Wilson A, Dawson MJ. Brown P, et al. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127163. doi: 10.1016/j.bmcl.2020.127163. Epub 2020 Mar 30. Bioorg Med Chem Lett. 2020. PMID: 32273214 Free PMC article.

3

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections.

Brown P, Dawson MJ. Brown P, et al. J Antibiot (Tokyo). 2017 Apr;70(4):386-394. doi: 10.1038/ja.2016.146. Epub 2017 Jan 11. J Antibiot (Tokyo). 2017. PMID: 28074057 Review.

4

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.

Brown P, Abbott E, Abdulle O, Boakes S, Coleman S, Divall N, Duperchy E, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ. Brown P, et al. ACS Infect Dis. 2019 Oct 11;5(10):1645-1656. doi: 10.1021/acsinfecdis.9b00217. Epub 2019 Sep 24. ACS Infect Dis. 2019. PMID: 31525992 Free PMC article.

5

Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.

Brown P, Abdulle O, Boakes S, Divall N, Duperchy E, Ganeshwaran S, Lester R, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ. Brown P, et al. ACS Infect Dis. 2021 Apr 9;7(4):894-905. doi: 10.1021/acsinfecdis.0c00917. Epub 2021 Mar 10. ACS Infect Dis. 2021. PMID: 33688718 Free PMC article.

6

The chemistry of Pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles.

Brown P, Davies DT, O'Hanlon PJ, Wilson JM. Brown P, et al. J Med Chem. 1996 Jan 19;39(2):446-57. doi: 10.1021/jm9503862. J Med Chem. 1996. PMID: 8558513

7

The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity.

Brown P, Best DJ, Broom NJ, Cassels R, O'Hanlon PJ, Mitchell TJ, Osborne NF, Wilson JM. Brown P, et al. J Med Chem. 1997 Aug 1;40(16):2563-70. doi: 10.1021/jm960738k. J Med Chem. 1997. PMID: 9258363

8

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

Miles TJ, Axten JM, Barfoot C, Brooks G, Brown P, Chen D, Dabbs S, Davies DT, Downie DL, Eyrisch S, Gallagher T, Giordano I, Gwynn MN, Hennessy A, Hoover J, Huang J, Jones G, Markwell R, Miller WH, Minthorn EA, Rittenhouse S, Seefeld M, Pearson N. Miles TJ, et al. Among authors: brown p. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7489-95. doi: 10.1016/j.bmcl.2011.09.117. Epub 2011 Oct 10. Bioorg Med Chem Lett. 2011. PMID: 22047689

9

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ. Jarvest RL, et al. Among authors: brown mj, brown p. Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8. doi: 10.1016/s0960-894x(02)01027-2. Bioorg Med Chem Lett. 2003. PMID: 12639554

10

Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Sit SY, Parker RA, Motoc I, Han W, Balasubramanian N, Catt JD, Brown PJ, Harte WE, Thompson MD, Wright JJ. Sit SY, et al. Among authors: brown pj. J Med Chem. 1990 Nov;33(11):2982-99. doi: 10.1021/jm00173a013. J Med Chem. 1990. PMID: 2231596

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