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Page 1
Cell Surface Remodeling of Mycobacterium abscessus under Cystic Fibrosis Airway Growth Conditions.
Wiersma CJ, Belardinelli JM, Avanzi C, Angala SK, Everall I, Angala B, Kendall E, de Moura VCN, Verma D, Benoit J, Brown KP, Jones V, Malcolm KC, Strong M, Nick JA, Floto RA, Parkhill J, Ordway DJ, Davidson RM, McNeil MR, Jackson M. Wiersma CJ, et al. Among authors: brown kp. ACS Infect Dis. 2020 Aug 14;6(8):2143-2154. doi: 10.1021/acsinfecdis.0c00214. Epub 2020 Jul 2. ACS Infect Dis. 2020. PMID: 32551551
Stepwise pathogenic evolution of Mycobacterium abscessus.
Bryant JM, Brown KP, Burbaud S, Everall I, Belardinelli JM, Rodriguez-Rincon D, Grogono DM, Peterson CM, Verma D, Evans IE, Ruis C, Weimann A, Arora D, Malhotra S, Bannerman B, Passemar C, Templeton K, MacGregor G, Jiwa K, Fisher AJ, Blundell TL, Ordway DJ, Jackson M, Parkhill J, Floto RA. Bryant JM, et al. Among authors: brown kp. Science. 2021 Apr 30;372(6541):eabb8699. doi: 10.1126/science.abb8699. Science. 2021. PMID: 33926925 Free PMC article.
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C. Charoensutthivarakul S, et al. Among authors: brown kp. ACS Infect Dis. 2022 Feb 11;8(2):296-309. doi: 10.1021/acsinfecdis.1c00432. Epub 2022 Jan 17. ACS Infect Dis. 2022. PMID: 35037462 Free PMC article.
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler IC, Chapman SJ, Clayton A, Cullen M, Daniels T, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O'Brien C, O'Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA. Bryant JM, et al. Among authors: brown kp. Science. 2016 Nov 11;354(6313):751-757. doi: 10.1126/science.aaf8156. Science. 2016. PMID: 27846606 Free PMC article.
Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus.
de Moura VCN, Verma D, Everall I, Brown KP, Belardinelli JM, Shanley C, Stapleton M, Parkhill J, Floto RA, Ordway DJ, Jackson M. de Moura VCN, et al. Among authors: brown kp. Front Microbiol. 2021 Jul 14;12:706207. doi: 10.3389/fmicb.2021.706207. eCollection 2021. Front Microbiol. 2021. PMID: 34335541 Free PMC article.
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.
Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. Renna M, et al. J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1. J Clin Invest. 2011. PMID: 21804191 Free PMC article.
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
Whitehouse AJ, Thomas SE, Brown KP, Fanourakis A, Chan DS, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Whitehouse AJ, et al. Among authors: brown kp. J Med Chem. 2019 Aug 8;62(15):7210-7232. doi: 10.1021/acs.jmedchem.9b00809. Epub 2019 Jul 19. J Med Chem. 2019. PMID: 31282680 Free PMC article.
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Thomas SE, et al. Among authors: brown kp. Front Mol Biosci. 2022 May 30;9:880432. doi: 10.3389/fmolb.2022.880432. eCollection 2022. Front Mol Biosci. 2022. PMID: 35712348 Free PMC article.
64 results