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254 results

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Page 1
Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy.
Lahrouchi N, Postma AV, Salazar CM, De Laughter DM, Tjong F, Piherová L, Bowling FZ, Zimmerman D, Lodder EM, Ta-Shma A, Perles Z, Beekman L, Ilgun A, Gunst Q, Hababa M, Škorić-Milosavljević D, Stránecký V, Tomek V, de Knijff P, de Leeuw R, Robinson JY, Burn SC, Mustafa H, Ambrose M, Moss T, Jacober J, Niyazov DM, Wolf B, Kim KH, Cherny S, Rousounides A, Aristidou-Kallika A, Tanteles G, Ange-Line B, Denommé-Pichon AS, Francannet C, Ortiz D, Haak MC, Ten Harkel AD, Manten GT, Dutman AC, Bouman K, Magliozzi M, Radio FC, Santen GW, Herkert JC, Brown HA, Elpeleg O, van den Hoff MJ, Mulder B, Airola MV, Kmoch S, Barnett JV, Clur SA, Frohman MA, Bezzina CR. Lahrouchi N, et al. Among authors: brown ha. J Clin Invest. 2021 Mar 1;131(5):e142148. doi: 10.1172/JCI142148. J Clin Invest. 2021. PMID: 33645542 Free PMC article.
FAM83B mediates EGFR- and RAS-driven oncogenic transformation.
Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, Jackson MW. Cipriano R, et al. Among authors: brown ha. J Clin Invest. 2012 Sep;122(9):3197-210. doi: 10.1172/JCI60517. Epub 2012 Aug 13. J Clin Invest. 2012. PMID: 22886302 Free PMC article.
Phospholipase D: enzymology, functionality, and chemical modulation.
Selvy PE, Lavieri RR, Lindsley CW, Brown HA. Selvy PE, et al. Among authors: brown ha. Chem Rev. 2011 Oct 12;111(10):6064-119. doi: 10.1021/cr200296t. Epub 2011 Sep 22. Chem Rev. 2011. PMID: 21936578 Free PMC article. Review. No abstract available.
Phospholipase D as a therapeutic target in brain disorders.
Lindsley CW, Brown HA. Lindsley CW, et al. Among authors: brown ha. Neuropsychopharmacology. 2012 Jan;37(1):301-2. doi: 10.1038/npp.2011.178. Neuropsychopharmacology. 2012. PMID: 22157867 Free PMC article. No abstract available.
Biochemical analysis of phospholipase D.
Brown HA, Henage LG, Preininger AM, Xiang Y, Exton JH. Brown HA, et al. Methods Enzymol. 2007;434:49-87. doi: 10.1016/S0076-6879(07)34004-4. Methods Enzymol. 2007. PMID: 17954242
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. Lavieri RR, et al. Among authors: brown ha. J Med Chem. 2010 Sep 23;53(18):6706-19. doi: 10.1021/jm100814g. J Med Chem. 2010. PMID: 20735042 Free PMC article.
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. Lewis JA, et al. Among authors: brown ha. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20. doi: 10.1016/j.bmcl.2009.02.057. Epub 2009 Feb 20. Bioorg Med Chem Lett. 2009. PMID: 19268584 Free PMC article.
254 results