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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation.
Fernández-García J, Franco F, Parik S, Altea-Manzano P, Pane AA, Broekaert D, van Elsen J, Di Conza G, Vermeire I, Schalley T, Planque M, van Brussel T, Schepers R, Modave E, Karakach TK, Carmeliet P, Lambrechts D, Ho PC, Fendt SM. Fernández-García J, et al. Among authors: broekaert d. Cell Rep. 2022 Nov 15;41(7):111639. doi: 10.1016/j.celrep.2022.111639. Cell Rep. 2022. PMID: 36384124 Free article.
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.
Manesia JK, Xu Z, Broekaert D, Boon R, van Vliet A, Eelen G, Vanwelden T, Stegen S, Van Gastel N, Pascual-Montano A, Fendt SM, Carmeliet G, Carmeliet P, Khurana S, Verfaillie CM. Manesia JK, et al. Among authors: broekaert d. Stem Cell Res. 2015 Nov;15(3):715-721. doi: 10.1016/j.scr.2015.11.001. Epub 2015 Nov 9. Stem Cell Res. 2015. PMID: 26599326 Free article.
Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.
Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland DW, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P. Quaegebeur A, et al. Among authors: broekaert d. Cell Metab. 2016 Feb 9;23(2):280-91. doi: 10.1016/j.cmet.2015.12.007. Epub 2016 Jan 7. Cell Metab. 2016. PMID: 26774962 Free PMC article.
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM. Vriens K, et al. Among authors: broekaert d. Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6. Nature. 2019. PMID: 30728499 Free PMC article.
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, van Gorsel M, Boon R, Escalona-Noguero C, Torrekens S, Verfaillie C, Verbeken E, Carmeliet G, Fendt SM. Elia I, et al. Among authors: broekaert d. Nature. 2019 Apr;568(7750):117-121. doi: 10.1038/s41586-019-0977-x. Epub 2019 Feb 27. Nature. 2019. PMID: 30814728 Free PMC article.
Analyzing the Metabolism of Metastases in Mice.
Altea-Manzano P, Broekaert D, Duarte JAG, Fernández-García J, Planque M, Fendt SM. Altea-Manzano P, et al. Among authors: broekaert d. Methods Mol Biol. 2020;2088:93-118. doi: 10.1007/978-1-0716-0159-4_6. Methods Mol Biol. 2020. PMID: 31893372
64 results