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Uncovering new families and folds in the natural protein universe.
Durairaj J, Waterhouse AM, Mets T, Brodiazhenko T, Abdullah M, Studer G, Tauriello G, Akdel M, Andreeva A, Bateman A, Tenson T, Hauryliuk V, Schwede T, Pereira J. Durairaj J, et al. Among authors: brodiazhenko t. Nature. 2023 Oct;622(7983):646-653. doi: 10.1038/s41586-023-06622-3. Epub 2023 Sep 13. Nature. 2023. PMID: 37704037 Free PMC article.
Direct activation of a bacterial innate immune system by a viral capsid protein.
Zhang T, Tamman H, Coppieters 't Wallant K, Kurata T, LeRoux M, Srikant S, Brodiazhenko T, Cepauskas A, Talavera A, Martens C, Atkinson GC, Hauryliuk V, Garcia-Pino A, Laub MT. Zhang T, et al. Among authors: brodiazhenko t. Nature. 2022 Dec;612(7938):132-140. doi: 10.1038/s41586-022-05444-z. Epub 2022 Nov 16. Nature. 2022. PMID: 36385533 Free PMC article.
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Kurata T, Saha CK, Buttress JA, Mets T, Brodiazhenko T, Turnbull KJ, Awoyomi OF, Oliveira SRA, Jimmy S, Ernits K, Delannoy M, Persson K, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. Kurata T, et al. Among authors: brodiazhenko t. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102212119. doi: 10.1073/pnas.2102212119. Proc Natl Acad Sci U S A. 2022. PMID: 35121656 Free PMC article.
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Ernits K, Saha CK, Brodiazhenko T, Chouhan B, Shenoy A, Buttress JA, Duque-Pedraza JJ, Bojar V, Nakamoto JA, Kurata T, Egorov AA, Shyrokova L, Johansson MJO, Mets T, Rustamova A, Džigurski J, Tenson T, Garcia-Pino A, Strahl H, Elofsson A, Hauryliuk V, Atkinson GC. Ernits K, et al. Among authors: brodiazhenko t. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305393120. doi: 10.1073/pnas.2305393120. Epub 2023 Aug 9. Proc Natl Acad Sci U S A. 2023. PMID: 37556498 Free PMC article.
RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.
Kurata T, Brodiazhenko T, Alves Oliveira SR, Roghanian M, Sakaguchi Y, Turnbull KJ, Bulvas O, Takada H, Tamman H, Ainelo A, Pohl R, Rejman D, Tenson T, Suzuki T, Garcia-Pino A, Atkinson GC, Hauryliuk V. Kurata T, et al. Among authors: brodiazhenko t. Mol Cell. 2021 Aug 5;81(15):3160-3170.e9. doi: 10.1016/j.molcel.2021.06.005. Epub 2021 Jun 25. Mol Cell. 2021. PMID: 34174184 Free article.