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SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. Chae H, et al. Among authors: broca c. Mol Metab. 2020 Dec;42:101071. doi: 10.1016/j.molmet.2020.101071. Epub 2020 Sep 5. Mol Metab. 2020. PMID: 32896668 Free PMC article.
Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells.
Fernandez-Ruiz R, García-Alamán A, Esteban Y, Mir-Coll J, Serra-Navarro B, Fontcuberta-PiSunyer M, Broca C, Armanet M, Wojtusciszyn A, Kram V, Young MF, Vidal J, Gomis R, Gasa R. Fernandez-Ruiz R, et al. Among authors: broca c. Nat Commun. 2020 Nov 25;11(1):5982. doi: 10.1038/s41467-020-19657-1. Nat Commun. 2020. PMID: 33239617 Free PMC article.
35 results