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Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Griebel G, Pichat P, Beeské S, Leroy T, Redon N, Jacquet A, Françon D, Bert L, Even L, Lopez-Grancha M, Tolstykh T, Sun F, Yu Q, Brittain S, Arlt H, He T, Zhang B, Wiederschain D, Bertrand T, Houtmann J, Rak A, Vallée F, Michot N, Augé F, Menet V, Bergis OE, George P, Avenet P, Mikol V, Didier M, Escoubet J. Griebel G, et al. Among authors: brittain s. Sci Rep. 2015 Jan 6;5:7642. doi: 10.1038/srep07642. Sci Rep. 2015. PMID: 25560837 Free PMC article.
mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B.
Cremosnik GS, Mesrouze Y, Zueger P, Furkert D, Grandjean F, Argoti D, Mermet-Meillon F, Bauer MR, Brittain S, Rogemoser P, Yang W, Giovannoni J, McGregor L, Tang J, Knapp M, Holzinger S, Buhr S, Muller L, Leder L, Xie L, Fernandez C, Nieto-Oberhuber C, Chène P, Galli GG, Sesterhenn F. Cremosnik GS, et al. Among authors: brittain s. ACS Chem Biol. 2024 May 17;19(5):1142-1150. doi: 10.1021/acschembio.4c00083. Epub 2024 Apr 24. ACS Chem Biol. 2024. PMID: 38655884
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter─Compounds with Novel Mechanisms from High-Throughput Screening Profiles.
Thomas JR, Shelton C 4th, Murphy J, Brittain S, Bray MA, Aspesi P, Concannon J, King FJ, Ihry RJ, Ho DJ, Henault M, Hadjikyriacou A, Neri M, Sigoillot FD, Pham HT, Shum M, Barys L, Jones MD, Martin EJ, Blechschmidt A, Rieffel S, Troxler TJ, Mapa FA, Jenkins JL, Jain RK, Kutchukian PS, Schirle M, Renner S. Thomas JR, et al. Among authors: brittain s. ACS Chem Biol. 2024 Apr 19;19(4):938-952. doi: 10.1021/acschembio.3c00737. Epub 2024 Apr 2. ACS Chem Biol. 2024. PMID: 38565185 Free PMC article.
Activation of human STING by a molecular glue-like compound.
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y. Li J, et al. Among authors: brittain sm. Nat Chem Biol. 2024 Mar;20(3):365-372. doi: 10.1038/s41589-023-01434-y. Epub 2023 Oct 12. Nat Chem Biol. 2024. PMID: 37828400 Free PMC article.
Understanding constraints to adaptation using a community-centred toolkit.
Buffa DC, Thompson KET, Reijerkerk D, Brittain S, Manahira G, Samba R, Lahiniriko F, Brenah Marius CJ, Augustin JY, Tsitohery JRF, Razafy RM, Leonce H, Rasolondrainy T, Douglass K. Buffa DC, et al. Among authors: brittain s. Philos Trans R Soc Lond B Biol Sci. 2023 Nov 6;378(1889):20220391. doi: 10.1098/rstb.2022.0391. Epub 2023 Sep 18. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37718606
70 results